Question

Question 1: Explain the pathophysiology of asthma.

Answer 1

The symptoms and signs of work-related asthma are almost the same as those of non-work-related asthma. Work-related asthma is discomfort caused by exposure to environmental or occupational sensitizers, irritants, or physical conditions. Regardless of the response, it triggers asthma and is characterized by inflammation, edema, bronchoconstriction, and a build-up of mucus in the airways, leading to coughing, wheezing, chest tightness, and shortness of breath.

Sensitizers

In particular, due to high molecular weight triggers, in the inflammation process and in the epithelial cells Cdc, pdfExternal and activates nitric oxide synthase, so it becomes nitric oxide forgiveness. Sensitizers are agents that initiate an allergic (immune) response. Latency is the first and carrots for several months at least sensitized efforts. Sensitizers are divided into low molecular weight and high molecular weight agents

High molecular weight agents (eg cereals, coffee beans, enzymes, flour, grain dust, vegetable proteins, shellfish, latex, wood dust) stimulate the production of autoimmunoglobulin E elements (isolation). During re-exposure and cross-linking, the agent activates specific antibodies to damage cells and release inflammatory mediators that lead to asthma symptoms.
Molecular weight, low agents: (example: acrylates, anhydrides, diisocyanates, dyes, formaldehyde, glutaraldehyde, metals, persulfate) are perfect antigens, said hapten, that combine to produce a protein with a sensitizing agent.
irritants

The answer is not allergic to be able to introduce include, gases, fumes, vapors, aerosols.
It is not the least reason to understand the nonummy scdit, an induced allergen.
physicals conditions

Exposure to cold air and physical labor.
Or warming airway inflammation is believed to lead to bronchoconstriction.

Asthma pathophysiology:

There are two classes of domain, asthma: extrinsic and intrinsic. Being attracted to brief outdoor asthma episodes is triggered by an irritant. It is basically an allergic reaction to the attraction of an allergen. It begins in childhood. Asthma improves as a person ages. In terms of triggers, an asthma attack should be brief, not external to itself. A respiratory tract infection, stress, exercise can trigger an asthma episode. Intrinsic asthma generally begins after age 30. Most patients experience a combination of both asthma.

Bronchoconstriction and bronchial inflammation are two important basic processes of asthma. In patients with asthma, the bronchi and bronchioles are very sensitive (hypersensitive) to irritants (allergens). This leads to inflammation of the irritating inflammatory reaction bronchoconstriction (contraction of the muscular wall of the arteries) an increase in mucus secretion in the respiratory lines.

The breath receives an allergen in the respiratory tract. These allergens are found to exhibit cell-bound antigen (APC). These PC cells "this" is an allergen that other immune cells "control" the allergen. They are not asthmatic for people, not for an allergen. However, compensated patients, these cells transform into TH2 cells, which are the human immune system in football. By attracting an allergen, antibodies are generated in response to immune ones and are displayed. This process reduces bronchial inflammation and airflow bronchospasm. Part of the increased number of eosinophils in asthma, neutrophils, lymphocytes, and plasma cells in bronchial tissues causes the related immune movement. This is often due to inflammation of the lungs and causes irreversible structural changes in the bronchi, the airways.