Question

Explain the pathophysiology of Multiple Sclerosis

Answer 1

MUULTIPLE SCLEROSIS

It is a condition in which the demyelination disease is occuring in the nerves. Myelin is the insulating covers of nerve cells in the brain and spinal cord. Theses are the one who insulates the unwanted impulses and also the impulses transmission is facilitated by the myelin. When this myelin or the protective covers of the are damaged the condition results in the MULTIPLE SCLEROSIS. This damage disrupts the ability of the parts of the nervous system and alters the transmit of impulses or signals, resulting in a range of signs and symptoms. The signs and symptoms include physical, mental, and sometimes psychiatric problems.

PATHOPHYSIOLOGY of MULTIPLE SCLEROSIS

Individuals who can move more pathologically defined as the presence of scarcely distributed glial (or cannot move the waist) in the central nervous system and many families in time (DIT) and space (thrust). The gold standard for the pathological diagnosis of MS is a relationship, even if the data is limited to the determination of the precise diagnostic methods normally used. Defining sclerosis is a disease that is the remnant of previous demyelinating lesions in the white matter Fotis patient (encephalomyelitis), which shows characteristics, such as the diameter of perivenous demyelination.

There are two phases to health loss:

* an unknown thing,

* the underlying cause of MS is what it is:

    An unknown soluble element (produced by CD8 T cells, B cells, or CD20) that Microglia operates creates a toxic environment.
- Magnetic resonance imaging will observe and gives out the ideas about the hidden damage to other areas of the brain and spine (NAWM, Nagma, DAWM). Microglia are activated by some groups, axonal transection of myelin degeneration is present.
- The brain barrier seeps into the blood and immune cells infiltrate, causing demyelination and destruction of axons. [eleven]

- Many different things cannot move around the diameter of subpial idiopathic demyelinating inflammatory disease in dura mater lesions. MS lesions, which have most of them, are found not only in patients with MS present, although currently they can only be detected by autopsy.

-Most accept the MS found within the white matter, and most of the defects seen in the periventricular distribution (hence the cerebral ventricles). In addition to white matter, the demyelination cortex and deep gray matter (GM) nuclei can be affected, along with lesions and diffuse NAWM. Speech-associated MS lesions of GM independent atrophy and physical disability, fatigue, cognitive decline in MS

The five safest now in MS patients with CNS tissue: inflammation beyond classic white matter lesions. Intrathecal Ig production with oligoclonal bands, an environment that encourages immune cells, and disruption of the blood-brain barrier outside the brain. active injuries. The scars are produced by the astrocyte situation that gives name to the healing of old injuries Until the launch of active MS.

Multiple sclerosis (MS) is an autoimmune disease in which the body begins to destroy the immune system. The immune system destroys the fatty tissue that isolates the myelin axon / spinal nerves in the brain area. The destruction of the myelin sheath, called demyelination. Central nervous system or CNS disease, which causes white matter in the brain to create plaque. Of the brain and spinal cord within the white spinal substance is present in the upper layer. And then the wedge plates try to send a signal to your contribution to the rest of the signals that the body is not quite correct in the nerve to be sent. This is the simplest explanation is Scdi MS. Signals to the brain and plaque injuries form by shutting down the problems that cause most symptoms. As the disease progresses, the nerves begin to destroy themselves.

And having continued with the MS disease, who was that is a Latin encyclopedia 4 according to the places, especially the sick, or felt worse. In the most effective treatments, however, it is proposed to stop the development of the disease, and in the early stages, in the form of a relapse, remitting it, as was said in a long period of time between relapses.
Protect healthy cells of the immune system to attack the external organs of the network of invasive bacteria and viruses, parasites, fungi that enter the invaders, etc. The body's immune system is configured. The immune system, which does not have the antigens, is another reason, another reason for this is the response depending on what attacked them. The clamor of any gene is enough to kill and satisfy it.

T cells play an important role in MS pathophysiology. The immune system can help destroy infected or organized damage and transport it directly to the cell. T cells that attack cells are important because they know the correct approach. Each of the cellular immune systems is the decision that says whether it is foreign or our own cell. Since MS is an autoimmune disease in the affected person, you don't know the difference between cells.

MS pathophysiology in the part of the blood-brain barrier (BBB).Membrane around the brain that allows blood to pass from the body unless the CNS. MS progresses as unintentionally and in defending the cause of loss and ignorance of the immune system to traverse the greatest virtue and results in damge ov the myelin or even the nerves

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