Briefly describe in words how a person on a low-carbohydrate diet could make glucose from alanine.

Expert Solution

Glucose –Carbohydrate cycle

Person on low carbohydrate diet, convert its non-essential alanine( present in skeletal muscle) in to glucose through converting itself in to pyruvate. The whole process happen between skeletal muscle and the liver. Under low carbohydrate condition, protein breakdown process exceed and this lead to libration of amino acid to blood stream. Alanine from skeletal muscle diffuses in to blood stream and reach to liver. In liver, alanine was deaminated and amino group was transfer form alanine to alpha-ketoglutarate to form pyruvate and glutamate. Aminotransferases or transaminases catalyzed this reaction present in liver hepatic cells. Pyruate produced such way is processed through gluconeogenesis to produce glucose.

Glucose ? Pyruvate ? Alanine ? Pyruvate ? Glucose

^{[ Following is the glucose- alanine cycle adopted from:
http://www.tuscany-diet.net/wp-content/uploads/2017/01/glucose-alanine-cycle.gif]}

gladiator answered 1 year ago

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