Question

Investigate the following drugs Gabapentin Lisinopril Synthroid • Identify the following criteria: History of drug (sometimes not much info) Indications/Contraindications Drug interactions Side effects Warnings

Answer 1

Gabapentin:

History: Gabapentin is an anti convulsant, was developed by Parke-Davis and was first described in 1975.

It was first approved under the brand name neurotimin in may 1993 for the treatment of epilepsy in UK.

Subsequently Gabapentin was approved in uk in 2002 for the treatment of postherapeutic neuralgia.

Indications :

1) partial seizures

2) postherapeutic neuralgia

3) Restless leg syndrome

4) Insomnia

5) Diabetic neuropathy

6) Tremors in multiple sclerosis etc.

Contraindications:

1) DelresDepr

2) myasthenia gravis

3) skeletal muscle disoredi

4) COPD

5) Chronic kidney disease

Drug interactions:

Drugs interacting with Gabapentin are Morphine, caffeine,losartan, ethacrynic acid, phenytoin, mefloquine. Etc

side effects

Drowsiness.

Dizziness.

Blurred vison.

Hypoventillation.

Respiratory failure.

Teratogenicity.

warning:

breathing problems.

Respiratory failure.

Lisinopril:

History: Lisinopril is an angiotensin converting enzyme (ACE) inhibitor.

Lisinopril is a synthetic peptide derivative of capropril.

Lisinopril is approved for hypertension in 1987.

Lisinopril approved for congestive heart failure in 1993.

Indications:

1) Hypertension

2) Congestive heart failure

3) myocardial infraction.

4) Prophylaxis in high risk cardiovascular problems.

Contraindications:

1) Hyperkalemia

2) History of angioedema

3) Renal failure with prior lisinopril use.

4) Bilateral renal artery stenosis.

5) concomitant use with aliskiren.

Drug interactions:

There are many drugs interacting with Lisinopril.

Some of them include Amphetamine, Amlodipine, Aspirin, Atenolol, carvedilol, ibuprofen, furosemide.metformin, metoprolol, tramedol etc.

Side effects:

Dizziness.

Headache.

Cough.

Decreased sexual ability

Heart burn.

Pain, burnunb, tingling in hand or feet.

warning:

Rarely cause serious liver problems.

Synthyroid (Levothyroxine):

History:

Levothyroxine is a manfactured form of thyroid hormone thyroxine.

The hormone was aynthesynthin 1927 by british chemists Charles Robert Harington and George Barger.

Indications:

Indicated as a replacement therapy in primary ( thyroidal), secondary (pituitary), tertiary (hypothalamic) congenital or acquired hypothyroidism.

Indicated as a adjunct to surgery or radioiodine therapy in the management of thyrotropin dependent well differentiated thyroid cancer.

Contra indications:

1) Over acting thyroid gland.

2) Thyrotoxicosis crisis.

3) diabetes

4) pituitary hormone deficiency

5) diabetes.

6) Osteoporosis

Drug interactions:

Drugs interacting with synthyroid are as follows

Amiodarone

Anti convulsant.

Antacids.

Beta blockers.

Birth control pills etc

Side effects:

Fever.

Hot flashes.

Sweating.

Nervous ness.

Headache.

Irritability.

Nausea.

warning:

Over treatment may cause detrimental cardiac problems.