What occurs differently when the P53 gene is mutated? Is this an oncogene or a tumor...

What occurs differently when the P53 gene is mutated?
Is this an oncogene or a tumor suppressor gene? How is that tied to its function? Why is this gene mutated in so many cancers?

Expert Solution

gladiator answered 2 years ago

How is a given protein, like P53, characterized as a tumor suppressor gene vs a proto-oncogene?...

How is a given protein, like P53, characterized as a tumor suppressor gene vs a proto-oncogene? Explain the difference between the two gene categories. With a protein in the ER, how does a secreted protein get to the plasma membrane via the golgi apparatus? Be sure to note the secretory pathway please help me on these two questions

6. The p53 tumor suppressor gene was isolated from a tumor where p53 protein levels were...

6. The p53 tumor suppressor gene was isolated from a tumor where p53 protein levels were very high. This was likely due to dominant-acting mutant that inactivated all p53 tetramers and blocked the tumor suppressing effects of wild type p53. A) True B) False 7. Increased gene expression from the Ink4A locus leads to inhibition of cyclin E-CDK2. A) True B) False 8. In colon cancer progression, the first driver mutation is commonly a mutation to the KRas gene. A)...

“For one oncogene or tumor suppressor gene, show how mutations in this gene contribute to various...

“For one oncogene or tumor suppressor gene, show how mutations in this gene contribute to various stages of cancer progression. Explain whether the protein product of the gene you have chosen is a favorable candidate as a drug target for anti-cancer therapy.”

What is the function of CDK-4 is it a proto-oncogene, tumor suppressor gene, or something else.

Why are tumor suppressor gene mutations recessive while oncogene mutations are dominant?

Explain why you cannot inherit an oncogene gene mutation but can inherit a tumor suppressor gene...

Explain why you cannot inherit an oncogene gene mutation but can inherit a tumor suppressor gene mutation.

Please Answer in Detail. Proto-oncogene or Tumor Suppressor? b-catenin: proto-oncogene or tumor suppressor? wnt: proto-oncogene or...

Please Answer in Detail. Proto-oncogene or Tumor Suppressor? b-catenin: proto-oncogene or tumor suppressor? wnt: proto-oncogene or tumor suppressor? APC (from wnt pathway): proto-oncogene or tumor suppressor? Frizzled: proto-oncogene or tumor suppressor? Ras: proto-oncogene or tumor suppressor? Ras-GAP: proto-oncogene or tumor suppressor? Map Kinase: proto-oncogene or tumor suppressor? P53: proto-oncogene or tumor suppressor? Myc: proto-oncogene or tumor suppressor? Cadherin: proto-oncogene or tumor suppressor? cAMP: proto-oncogene or tumor suppressor? Receptor Tyrosine kinases: proto-oncogene or tumor suppressor? M-Cyclin-dependent kinase (cdc2) : proto-oncogene or...

What is/are the phenotypes when the SALL4 gene is mutated at the molecular level? What process...

What is/are the phenotypes when the SALL4 gene is mutated at the molecular level? What process is interfered with?

What is protein that is related to p53 gene? How is this gene regulated? What is...

What is protein that is related to p53 gene? How is this gene regulated? What is the protein that is formed? What is specific structure, what is function of this protein? How is this protein regulated post-translationally?

1.Explain the difference between an oncogene and a tumor suppressor gene. 2.Signal transduction cascades amplify hormonal...

1.Explain the difference between an oncogene and a tumor suppressor gene. 2.Signal transduction cascades amplify hormonal signals. How does cAMP contribute to signal amplification?

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