How is a given protein, like P53, characterized as a tumor
suppressor gene vs a proto-oncogene? Explain the difference between
the two gene categories.
With a protein in the ER, how does a secreted protein get to the
plasma membrane via the golgi apparatus? Be sure to note the
secretory pathway
please help me on these two questions
“For one oncogene or tumor suppressor gene, show how mutations
in this gene contribute to various stages of cancer progression.
Explain whether the protein product of the gene you have chosen is
a favorable candidate as a drug target for anti-cancer
therapy.”
1.Explain the difference between an oncogene and a tumor
suppressor gene.
2.Signal transduction cascades amplify hormonal signals. How
does cAMP contribute to signal amplification?
What occurs differently when the P53 gene is mutated?
Is this an oncogene or a tumor suppressor gene? How is that
tied to its function? Why is this gene mutated in so many
cancers?
Describe the role of proto-oncogenes/oncogenes OR tumor
suppressor genes in the development of cancer.
RNA processing splices introns out of pre-mRNA producing mature
mRNA. Describe what happens when some genes undergo alternative
splicing.
6. The p53 tumor suppressor gene was isolated from a tumor where
p53 protein levels were very high. This was likely due to
dominant-acting mutant that inactivated all p53 tetramers and
blocked the tumor suppressing effects of wild type p53. A) True B)
False
7. Increased gene expression from the Ink4A locus leads to
inhibition of cyclin E-CDK2. A) True B) False
8. In colon cancer progression, the first driver mutation is
commonly a mutation to the KRas gene. A)...