How is a given protein, like P53, characterized as a tumor
suppressor gene vs a proto-oncogene? Explain the difference between
the two gene categories.
With a protein in the ER, how does a secreted protein get to the
plasma membrane via the golgi apparatus? Be sure to note the
secretory pathway
please help me on these two questions
“For one oncogene or tumor suppressor gene, show how mutations
in this gene contribute to various stages of cancer progression.
Explain whether the protein product of the gene you have chosen is
a favorable candidate as a drug target for anti-cancer
therapy.”
Describe the role of proto-oncogenes/oncogenes OR tumor
suppressor genes in the development of cancer.
RNA processing splices introns out of pre-mRNA producing mature
mRNA. Describe what happens when some genes undergo alternative
splicing.
Yes or no, is this encoded by a proto-oncogene? (Please respond
with Yes or No)
1. MAPKINASE (MAPK)
2. RB (inhibitor of cyclin dependent kinase)
3. BAX (promotes apoptosis)
4. BAD (an inhibitor of BCL2; BCL2 inhibits BAX)
5. P53
6. Cyclin
Which is NOT a typical mechanism by which a proto-oncogene is
converted to an oncogene?
a. A chromosomal translocation that brings together two
different genes that make a fusion protein.
b. A chromosomal translocation resulting in enhanced
transcription of the proto-oncogene.
c. Complete deletion of the proto-oncogene.
d. A point mutation in the proto-oncogene.
e. All of the above are mechanisms of converting
proto-oncogenes to oncogenes.
1.Explain the difference between an oncogene and a tumor
suppressor gene.
2.Signal transduction cascades amplify hormonal signals. How
does cAMP contribute to signal amplification?
Are tumor suppressor or oncogenes likely to be linked to genetic
factors? Please explain how these two types of cancer-causing genes
lead to cancer in context of genetic causes.