Question

What physical and chemical properties would you want lowagliflozin (type 2 diabetes medicine) to have to be a good candidate for phase 1 clinical trials?

Answer 1

The above mentioned lowagliflozin is not relevant drug for type 2 diabetes mellitus treatment ie the mentioned drug name is alphabetically incorrect. So I will give you an answer about the group of drugs with name 'flozin' which is used for the treatment of type 2 diabetes mellitus,

Flozin group of drugs also called glioflozins includes dapagliflozin, empagliflozin etc. acts as a SGLT-2 (Sodium glucose Cotransporter -2) inhibitors. They will help in lowering the blood glucose levels in type 2 diabetes mellitus.

The Physical and chemical properties of flozin drugs to have to be a good candidate for phase1 clinical trials are:-

• It have improved insulin sensitivity.
• It helps in maintaining normal glucose concentration in plasma without leading to hypoglycemia.
• The bioavailability of these drugs are much greater.
• SGLT-2 inhibiting action of these drugs may having direct renoprotective effects.
• These drugs also have the properties for reduce the tubular toxicity of glucose.
• Chemically, the SGLT-2 inhibitor like dapagliflozin have c-glucoside which is not degraded by the beta-glucosidase and also have better half life and duration of action.
• These drugs also have the properties in glycemic control type 2 diabetes mellitus.
• Structurally they are having c-glucoside bearing thiazole at the distal ring on heterocyclic ring shows good physicochemical properties that can lead to clinical development.