Question

PLEASE Complete the blanks in the following “story” of lipoprotein metabolism

Once upon a time there was a little girl named Alice who ate a double bacon cheeseburger for lunch. After digesting the __________________ in the burger using pancreatic __________, they used a ___________ to cross the unstirred water layer of the small intestine and enter the enterocyte. Once inside the enterocyte, the ___________________ were re-assembled and packaged into a _____________________ with the protein apoB_____ and released first into the _________ and then the __________. During circulation, the chylomicron bumped into it’s friend the happy little HDL particle, which gave the chylomicron two important apoprotein “gifts” named apo_____ and apo_____. The chylomicron was now ready to do its job of delivering _____________ triglycerides to the cells. The chylomicron floated along in the capillary until it docked with __________________________(activated by apo_____), which hydrolyzed the triglyceride to 1 _________ and 3 ___________________ which were taken up by the cell. After releasing its triglycerides, the chylomicron gave back the apo_____ to HDL and became a chylomicron _________________, which was taken up by the liver (whose receptors recognized the apo____ and apo____) and cleared it from circulation.

After eating the double bacon cheeseburger, Alice was very thirsty so she decided that she would drink a 2-liter bottle of soda sweetened with high fructose corn syrup. Because Alice had exceeded her calorie needs for the day, much of the fructose in the soda was converted to ____________ in the liver and used as the backbone for endogenous _____________________ synthesis. The liver took these ________________ triglycerides and packaged them into a ___________________________ with the protein apoB_____. After this nascent _________ was released into circulation, it bumped into it’s friend the happy little HDL particle, which gave the nascent _______ two important apoprotein “gifts” named apo_____ and apo_____, making a mature ________ particle. The mature ________ was now ready to do its job of delivering _____________ triglycerides to the cells. The VLDL floated along in the capillary until it docked with __________________________(activated by apo_____), which hydrolyzed the triglyceride to 1 _________ and 3 ___________________ which were taken up by the cell. As LPL pulled much of the __________________ out of VLDL, the VLDL particle became smaller and more enriched in _______________.

The VLDL particle liked getting smaller and was therefore jealous of its friend the happy little HDL particle, who was the smallest of all the lipoproteins. Therefore, the next time the VLDL particle bumped into the HDL, it made sure that it found a _____________________ to help steal cholesterol esters from the HDL particle and in exchange gave some of its _________________ and phospholipids to HDL. This made the VLDL particle even smaller with less triglyceride and more cholesterol esters, transforming the VLDL into an ________ and then (once the amount of cholesterol was greater than the amount of triglyceride) a ________. Since the VLDL had given back the apo_____ and apo _____ to HDL after the VLDL had released its triglycerides, the only apoprotein remaining on the LDL was apo______.

So now our friend the little LDL particle was ready to do its job of delivering ______________ to the cells. The LDL floated along until it docked with the ____________________ (which recognized the apo______) on the outside of the cell membrane and then the cell engulfed the entire _______ particle, removing it from circulation.

Because Alice had a very high saturated fat diet, she had an excess of cholesterol in her blood. Fortunately, Alice’s liver made the happy little nascent________ particle, who had a flat disc shape and contained apo______, apo______, and apo______. As this happy little particle circulated in the blood, it donated the apo_____ and apo______ to VLDL (and CMs) and became more spherical in shape as it picked up free _______________ from tissues and trapped it inside by esterifying it to make a ______________ ester. The enzyme that helped “trap” the cholesterol inside the _______ particle was named _____________________________, and this enzyme was activated by apo______. Although some of the cholesterol esters inside the ______ particle were transferred to VLDL in exchange for triglycerides and phospholipids by the __________________________________, the HDL was still able to keep much of the cholesterol inside and go back to the liver, which recognized the apo_____ and engulfed the HDL particle. And this is how our friend the happy little HDL takes cholesterol back to the liver, a process called “reverse _________________.”

Answer 1

Due to shortage of time and also lack of space , i chouldnt attempt the second part. And please excuse my some mistakes. I hope you have understood the apo B 48 and Dietary triglycerides instead of lipoprotein and free fatty acids respectively which i have written mistakenly.