Question

Similar genes (homologs) are found in humans. Do you expect the expression of these genes to be similar during human development? During cancer development?

Answer 1

Homologous or Homolods are two or more genes that descend from a common ancestral DNA sequence. Orthologous and paralogous genes are different types of homologous genes. . An example of homologous genes are the genetic codes underlying a bat wing and a bear arm. Both retain similar features and are utilized in similar manners.

During Human Development: Paralogous or paralogs, are genes that are created not by speciation but by mutated gene duplication within a single species. The most famous example of this are the paralogs myoglobin and hemoglobin. Myoglobin is a binding protein found in muscle tissues, and hemoglobin is a binding protein found in blood.

During Cancer Development: Homologous recombination as another mechanism that can result in a loss of heterozygosity or genetic rearrangements. Some of these genetic alterations may play a primary role in carcinogenesis, but they are more likely to be involved in secondary and subsequent steps of carcinogenesis by which recessive oncogenic mutations are revealed.