Mutations can occur in mRNA as well as DNA. Explain why a mutation in mRNA is...

Mutations can occur in mRNA as well as DNA.

Explain why a mutation in mRNA is not likely to have serious consequences.

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Expert Solution

Mutation rate are high in mRNA Compare to DNA but in RNA mutation does not have greater consequences compare to DNA mutation because

mRNA have short life once protein is form it get degraded thus not affect as much compare to DNA which is genetic material.
The mutation in mRNA if usually occur in higher frequency in intron which is spliced off and does not play role in mature mRNA formation so protein translated from mature mRNA is not affected.
Even in exon if mutation in case synonymous mutation the degeneracy of codon play crucial role where many codon code for same Amino acid so doesn't effect the protein structure and function while in case of non synonymous mutation where the codon change lead to non function protein formation is degraded through Proteosoma degradation.

From above all we can conclude the mRNA mutation do not have greater impact but DNA which is a genetic material and blue print for the cell function and survival get mutated lead to defect in cell and disease in an organism

gladiator answered 1 year ago

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