Question

Which of the following statements about the basal ganglia and Parkinson’s disease is FALSE?

		The four cardinal motor features of Parkinson’s disease are tremor at rest, postural instability, rigidity, and slowness of movement.
		Exciting striatal neurons in the Direct Pathway increases basal ganglia inhibition of the thalamus, which blocks movement.
		A loss of approximately 80 - 90% of SNc (substantia nigra pars compacta) dopamine containing neurons causes the motor symptoms of Parkinson’s disease.
		Deep brain stimulation appears to work by reducing hypersynchronized beta oscillations in the basal ganglia that occur with Parkinson’s disease.

Answer 1

False statement

*Exciting striatal neurons in Direct pathway Increases Basal ganglia inhibition of thalamus which blocks movement .

Actually Striatal neurons act through Direct and Indirect pathway .Direct pathway excites the basal ganglia and through the motor cortex cause increase firing and cause movement .Indirect pathway inhibits the basal ganglia and through the motor cortex causing Decrease firing and decrease the movement not required.Proper cordination between direct and Indirect pathway required for smooth coordinated movement .

others are correct statements .

Parkinsonism is degenerative disease characterised by degeneration of Substantia Nigra pars campacta .Triad is Tremors ,Rigidity ,Bradykinesia and Postural instability .

Deep brain stimulus works by stimulating subthalamus in Parkinsonism disease by reducing hypersynchronised beta stimulations in basal ganglia and decreasing movements .