a. For each glucose molecule removed from the nonreducing end of glycogen in mammalian skeletal muscle...

a. For each glucose molecule removed from the nonreducing end of glycogen in mammalian skeletal muscle what is the theoretical maximum number of ATPs produced under anaerobic conditions

b. If one molecule of eicosanoic acid (20:0) were metabolized in mammalian tissues under aerobic conditions what is the theoretical maximum number of ATPs produced

Solutions

Expert Solution

a. For each glucose molecule removed from the nonreducing end of glycogen in mammalian skeletal muscle what is the theoretical maximum number of ATPs produced under anaerobic conditions.

3 ATPs (4-1=3).

4 ATPs are produced from 1 glucose via anaerobic glycolysis. 1 ATP is consumed for the conversion of fructose-6-phosphate to fructose-1,6-bisphosphate (3rd step of glycolysis).

b. If one molecule of eicosanoic acid (20:0) were metabolized in mammalian tissues under aerobic conditions what is the theoretical maximum number of ATPs produced.

165 ATPs.

Eicosanoic acid (20 carbon) produces 10 acetyl-CoA, 9 NADH, and 9 FADH2 via β-oxidation.

1 acetyl-CoA produces 3 NADH, 1 FADH2, and 1 GTP via TCA cycle.

10 acetyl-CoA produces 30 NADH, 10 FADH2, and 10 GTP via TCA cycle.

Totally, eicosanoic acid produces via β-oxidation and TCA cycle,

39 NADH = 117 ATP (39x3) (1 NADH generates 3 ATP via ETC)

19 FADH2 = 38 ATP (19x2) (1 FADH2 generates 2 ATP via ETC)

10 GTP =10 ATP.

Total = 165 ATPs are produced by complete metabolism of one molecule of eicosanoic acid (20:0) under aerobic conditions.

gladiator answered 1 year ago

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