The nucleophile that is used to free most glucose from glycogen is__________, and Glycogen phosphorylase is...

The nucleophile that is used to free most glucose from glycogen is__________, and Glycogen phosphorylase is active when it is _________________.

1. ATP

2. Tyrosine

3. Serine

4. Inorganic phosphate

5. Water

6. Hydroxide

A. Phosphorylated

B. Not phosphorylated.

C. Denatured.

Solutions

Expert Solution

Answer. The nucleophile that is used to free most glucose from glycogen is inorganic phosphate and glycogen phosphorylase active when it is phosphorylated.

4 and B

In muscle, epinephrine causes activation of protein kinase A (PKA). PKA promotes glycogen degradation indirectly by phosphorylating and thus activating a kinase, glycogen phosphorylase kinase, that in turn phosphorylates and activates glycogen phosphorylase, the enzyme that degrade glycogen. The dimeric skeletal muscle glycogen phosphorylase exists in two interconvertible forms: active phosphorylase a and inactive phosphorylase b. Phosphorylase b is converted into phosphorylase a when it is phosphorylated at a single serine residue in each subunit.

gladiator answered 1 year ago

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