In: Nursing
1. What responses does the sympathetic nervous system regulate?
Answer: -
The following are the responses of sympathetic nervous system
a. Dilates pupil
b. Inhibits salivation
c. Bronchial dilation
d. Inhibits digestion
e. Increase heart rate
f. Stimulates glucose release from liver
g. Stimulates epinephrine and norepinephrine release from kidneys
h. Relaxes bladder
i. Contracts rectum
j. Ejaculation of sperm
k. Increases contractility of small intestine and large intestine
2. Discuss the cholinergic drugs and their possible actions, including adverse side effects.
Answer:
Cholinergic drugs are those drugs which act upon neurotransmission especially parasympathetic nervous system. cholinergic agonists work by directly binding to and activating the muscarinic receptors.
Action: cholinergic drugs act upon cholinesterase enzyme stimulating the production of acetyl choline at neuro-neuronal junction, causing more neural response. They may also be called as mimicking agents for neuro transmission as they increase impulses within parasympathetic nervous system.
Indications: myasthenia gravis, dementia, ophthalmology, post-operative urinary retention, neurogenic bladder, xerostomia, anticholinergic overdose, tensilon test. Etc…
Adverse effects: constriction of pupil, bronchial constriction, narrowed airway, increased salivation, bradycardia, hypotension, head ache, dizziness, convulsions, abdominal cramps.
3. What client education is appropriate for clients receiving pharmacotherapy with cholinergic drugs? Cholinergic blocking drugs?
Educate the client about possible uses of the anti-cholinergic drugs,
These are the drugs which block the parasympathetic nervous system stimulation by blocking the neuro – neuronal junction.
Educate that these drugs decrease all kinds of secretions
Educate that these decrease the peristalsis movement
Educate that these drugs cause bronchodilation and decreases respiratory secretions
Educate that these drugs are used with caution in patients with GI infections, benign prostatic hypertrophy, urinary retention, hyperthyroidism, hepatic or renal disease, and hypertension.
4.What types of responses that occur when drugs activate alpha1-, alpha2-, beta1-, beta2- or beta3-adrenergic receptors. Give an example of a medication for each.
These are adrenergic drugs which binds to adrenergic receptors all over the body
The responses of these are as follows
Receptor |
Action |
Drug of choice |
Alpha-1 receptor: |
Smooth muscle contraction, mydriasis |
Phenylephrine |
Alpha-2 receptor: |
Mixed smooth muscle effects |
Methyldopa |
Beta-1 receptor: |
Increased cardiac chronotropic and inotropic effects |
Dobutamine |
Beta-2 receptor: |
Bronchodilation |
Albuterol |
Beta-3 receptor: |
Increased lipolysis |
Mirabegron |