Question

What are some of the strategies of the antiretroviral drugs used in AIDS treatment?

Answer 1

• HIV treatment involves taking medicines that slow the progression of the virus in your body. HIV is a type of virus called a retrovirus, and the drugs used to treat it are called antiretrovirals (ARV). These drugs are always given in combination with other ARVs; this combination therapy is called antiretroviral therapy (ART). Many ART drugs have been used since the mid-1990s and are the reason why the annual number of deaths related to AIDS has dropped over the past two decades.
• The introduction of Antiretrovirals has changed the course of HIV disease from invariably fatal illness to chronic but manageable one. Preferred viral suppression treatment includes Protease inhibitorIntegrase inhibitor, nucleoside reverse transcript inhibitor, gp protein inhibitors, etc., which were proven to suppress antiretroviral activity. Antiretroviral therapy refers to the use of pharmacologic agents that have specific inhibitory effects on HIV replication. Antiretroviral agents belongs to six distinct classes of drugs, the nucleoside and nucleotide reverse transcriptase Inhibitors, The non nucleoside reverse transcriptase Inhibitors, The protease Inhibitors, The fusion inhibitors, The CRR 5 Co receptor antagonistic and The Integrase Inhibitors]. Antiretroviral therapy for the treatment of human immunodeficiency virus infection has improved steadily since the advent of potent combination therapy in 1996. New drugs have been approved that offer new mechanisms of action, improvements in potency and activity even against multidrug-resistant viruses, dosing convenience, and tolerability . Accurate quantification of HIV-1 Viral Load (VL) in plasma compartment is crucial for disease monitoring and management in HIV . After active anti retroviral therapy have become standard a few issues of such therapy have been clarified; still many points remained incompletely understood . Highly active antiretroviral therapy (HAART) has significantly changed the morbidity and mortality associated with HIV-1 infection. A nonnucleoside reverse transcriptase inhibitor (NNRTI) combined with two or three nucleoside reverse transcriptase inhibitors have shown better results