Question

Describe Type 1 diabetes in terms of the adaptive immune response that mediates it and what effect the autoimmune disease can have on the host.

Answer 1

Type 1 diabetes mellitus is occuring due to destruction of the islets cells of Langerhans.

The main cause are  

1. The cells in our body that will escape the specific kind of the deletion process in our thymus
2. Specific impaired and abnormal t cells that escape the peripheral tolerance
3. They trigger the antigen and the B lymphocytes in our human body to trigger the reaction that is to secrete antibody against the cells in our human body especially to the islet of Langerhans cells
4. The ability of T cells to look alike that is clone t cells who will not get destroyed in the thymus is the Amin reason for trigger of antibodies production by b cells

. This autoimmune disease on host can cause destruction of specific cells and structure in human body . The organ in type 1 diabetes is the destruction of islet cell of Langerhans which produces insulin in human body . Their destruction will lead to lack of insulin in human body and inability to produce insulin. This will lead to ketogenic disorders and fruity smelling breath . They need lifelong insulin therapy for the specific condition