What role does TdT play in antibody production? What role does Rag1/2 play in antibody production?

A. What role does TdT play in antibody production?

B. What role does Rag1/2 play in antibody production?

Expert Solution

answer for part A) First of all it is essential to know what is TdT and then only we can understand its role in antibody production.

TdT - Terminal Deoxynucleotidyl Transferase

1. TdT is a lymphoid( present in lymphoid organ ) specific DNA polymerase enzyme .

2. It plays a major role in generating diversity of lymphocyte antigen receptor during V(D)J recombination .

so basically it produces Tag and Bag (ag=antigen) receptor diversity.

now , we know that a antigen binds to a antibody , which is the T and B cell recetor in this case , which are produced by V(D)J recombination( it is a phenomenon of cutting , shuffling ,and then recombining of hundreds of VDJ genes , resulting in a wide diversity of antibodies for specific antigens ).

TdT exerts diversification in various antibody receptors in T and B cell by adding non template nucleotides at V(D)Junctions of these receptors, thus producing different antibodies.

So this how TdT plays a role in antibody production .

answer to part B) Again , to understand the role of any gene or protein in any phenomena in a biological system, we must first know what the gene or protein is , and its precise function...

so moving on : WHAT IS RAG ???

RAG - which is Recombination Activating Genes , Produce two main proteins RAG 1 and RAG 2 both present on chromosome 11 p13 (locus). and works as a multisubunit protein.

basically , RAG encodes for an enzyme (proteinaceous complex) which plays a key role in rearrangment and recombination of the genes of immunoglobulins ( which are antibodies) and T CELL receptor molecules.

The two proteins RAG1 and RAG2 are essential for generation of mature B and T lymphocytes (note that - reaarangment and shuffling mainly occurs inside B and T cell during their maturation )which are crucial in our adaptive immune response and adaptive immune responses is mainly the antibody production against any specific antigen encountered by the body .

gladiator answered 2 years ago

What role does antibody play in Trypanosoma brucei infections? What role does VSG play in T....

What role does antibody play in Trypanosoma brucei infections? What role does VSG play in T. brucei infections? Using your knowledge of antibodies explain how the trypanosome survive within the host to ensure transmission to new hosts? How does the parasite evade the host immune system?

What role does antibody play in Trypanosoma bruceiinfections? What role does VSG play in T. bruceiinfections?

This is for AT&T: What role does materials technology play in the production of the organization’s...

This is for AT&T: What role does materials technology play in the production of the organization’s goods or services?

What is an ERDM, and what role does it play in the modern (production) database environment?

What is an ERDM, and what role does it play in the modern (production) database environment?Describe the basic features of the relational data model and discuss their importance to the end user and the designer.

Does social media play a role in advertising? If so, what role does it play?

What role does materials technology play in the production of the organization’s goods and services?

what role does consumption play in shaping your sense of self? what role does it play...

what role does consumption play in shaping your sense of self? what role does it play in our society?

Q1. What role does the accounting department play (or what role should it play) in the...

Q1. What role does the accounting department play (or what role should it play) in the budgeting process? In the end, who is ultimately responsible for the budget, anyway? Instead of the president of the company, would it be more effective if the budgeting committee as a whole was responsible for the budget? Q2. Who should represent the various departments in the budget committee? What are the roles of these individuals?

What role does phosphorus play?

What role does the manifold and production header play in a surface facility designed for reservoir fluids production?

Question