Question

in supercritical fluid chromatography the separation is conducted under subcritical conditon, what is the detector system should be avoided under subcritical condition and why?

Answer 1

Answer: According to the question , Here Supercritical fluid chromatography (SFC) can be used on an analytical scale, where it combines many of the advantages of high performance liquid chromatography (HPLC) andgas chromatography (GC). It can be used with non-volatile and thermally labile analytes (unlike GC) and can be used with the universal flame ionization detector (unlike HPLC), as well as producing narrower peaks due to rapid diffusion. In practice, the advantages offered by SFC have not been sufficient to displace the widely used HPLC and GC, except in a few cases such as chiral separations and analysis of high-molecular-weight hydrocarbons. For manufacturing, efficient preparative simulated moving bed units are available.The purity of the final products is very high, but the cost makes it suitable only for very high-value materials such as pharmaceuticals.

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