Question

Describe how homozygous Factor V Leiden would be identified and explain the coagulation issue that would be expected in a patient demonstrating this condition.

Answer 1

Factor v leiden is a cogulation disorder. Factor v is a protein responsible for the clotting mechanism . Absence of this protein leads to cogulation disorder. Some individuals dont have factor v , those individuals have factor v leiden. This happens due to the mutation of the factor v gene.

○Two types of factor v leiden are there

Heterozygous and homozygous factor v leiden

If an individual get one factor v leiden gene from one parent it is heterozygous

If an individual get two factor v leiden gene then it is homozygous.

Factor v helps the blood to form clot. Another protein called activated protein c controls factor v , and it stops blood from clotting. In normal people there is a balance mechanism among these proteins.

▪Factor v leiden can be identified by blood test . Blood test is carried to find the activated protein c resistance .

▪DNA test is done to find the factor v leiden and its type. in case of homozygous  the individual have complete factor v leiden and no normal factor v. In heterozygous50% normal and 50 % mutated one ( factor v leiden)

Coagulation issues

People living with factor v leiden have clotting isses. Having a mutated  factor v leads to increased risk of deep vein thrombosis, pulmonary embolism . Homozygous type is more dangerous than heterozygous, as they have 100 % mutated gene ( factor v leiden).

Factor v leiden do not produce heart attack or stroke.