Question

1. Explain the impact of the body’s glucose levels on fatty acid catabolism and fatty acid synthesis (10 points).

Answer 1

1. A glucose effect on fatty acid metabolism could be controlled by either regulation of lipolysis or control pf fatty acid okidation .The glucose infusion or ingestion inhibits lipolysis and decreases the release of fatty acids into the blood
2. Inhibition of fatty acid oxidation has been shown previously to lower blood glucose levels acutely in daibetic rats
3. glucose and fatty acid metabolism plays a major role in development of insulin resistance in skeletal muscle.
4. insulin breakdown of fat in adipose tissue by inhibiting the intracellular lipase that hydrolyzes triglycerides to release fatty acids
5. insulin facilitates the entry of glucose into adipocytes and within those cells , glucose can be used to synthesize glycerol
6. the regulation of adipose tissue lipolysis occupies a key position in the metabolic concert of carbohydrates and lipids
7. insulin plays role of conductor to inhibit lipolysis
8. to increase the glucose uptake, lipgenesis and reesterification of free fatty acids
9. fat build up inside cells create toxic fatty breakdown products and free radicals that block the insulin signaling process close the glucose gate and make blood sugar levels rise
10. this level variation seen in evidence in blood work