In: Biology
1- Fatty acyl CoA synthetase catalyses the 2-step fatty acid activation prior to fatty acid synthesis.
True
False
2- Individuals with defects in ammonia clearance tend to suffer neurological problems due to influx of calcium ions into the brain.
True
False
3-Maple syrup disease is largely cause by a defect in the biosynthesis of branched-chain amino acids such as isoleucine.
True
False
4- Uridylylation of PII stimulates the formation of glutamine from glutamate.
True
False
5- Which of the following enzymes catalyzes a highly regulated step involved in both amino acid synthesis and amino acid degradation?
Alanine aminotransferase |
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Aspartate aminotransferase |
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Glutamate dehydrogenase |
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Glutamine synthetase |
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None of the above |
6- The binding of CO to hemoglobin causes it to remain in what conformational state?
Denatured state |
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R state |
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T state |
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Unbound state |
Ans .(1) True
The oxidative degradation of fatty acids is a two-step process , catalyzed by acyl CoA synthetase. First, the fatty acid reacts with ATP to form an acyl phosphate. This intermediate reacts subsequently to give acyl-CoA.
Fatty acids are activated in cytosol but oxidation occurs in mitochondria.
Ans .(2) True
Ammonia in brain causes cerebral edema.
The ammonia is responsible for a change in the pH and an increase in calcium.
Ans .(3) True
Maple syrup urine disease is an inborn error of metabolism caused by defects in the branched chain -keto acid dehydrogenase complex, which results in elevations of the branched chain amino acids such as isoleucine in plasma.
Ans .(4) True
Ans .(5) Alanine aminotransferase
Alanine aminotransferase catalyzes the transfer of amino group of alanine to -ketoglutarate.These transamination reactions are reversible and can thus be used to synthesize amino acids from - ketoacids.
Ans .(6) R state
Once Carbon monoxide binds to one site of hemoglobin, hemoglobin turns into the R-state.
Carbon monoxide exerts its toxic effect by stabilizing the R form of hemoglobin.