Describe the structure of a zinc finger motif

Solutions

Expert Solution

A zinc finger is a structural motif of protein. It is characterised by the co-ordination of one or more zinc ions. The name zinc finger comes from finger like appearance of transcription factor IIIA which was discovered from Xenopus sp. The structure has multiple finger like protrusions which makes contact with the target molecule. The finger like folds are stabilised by salt bridges. They co-ordinate zinc ions with a combination of cysteine and histidine residues. The zinc finger can be classified into fold groups based on the shape of backbone of protein in the domain. The types include classic zinc finger, treble clef and zinc ribbon. In the classic zinc finger motif, two of the ligands form a knuckle while the other two form the C terminus of the helix. In treble clef, the structure is more or less similar to classic zinc finger except for the fact that the 3rd and the 4th ligands form the N terminus of the helix. In zinc ribbon, two ligands forms two knuckles.

gladiator answered 1 year ago

Next > < Previous

Related Solutions

Protein domain with zinc finger motifs are frequently used to interact with a specific sequence of...

Protein domain with zinc finger motifs are frequently used to interact with a specific sequence of DNA and found in many activators. A.True B.False

The right pinky finger : Describe the formation of lymph within right pinky finger , relating...

The right pinky finger : Describe the formation of lymph within right pinky finger , relating that to blood vessels within the right pinky finger and addressing the physical forces that lead to lymph production. How would the lymph that is formed in right pinky finger be returned to the blood supply? What vessels and lymph organs would it travel through? For the second part of your discussion imagine that there is a potential pathogen within your identified region -...

How many moles of zinc are in 4.80 kg of zinc?

± Introduction to Electroplating Learning Goal: To relate current, time, charge, and mass for electroplating calculations. Electroplating is a form of electrolysis in which a metal is deposited on the surface of another metal. To quantify electrolysis, use the following relationships. Electric current is measured in amperes (A), which expresses the amount of charge, in coulombs (C), that flows per second (s): 1 A=1 C/s Another unit of charge is the faraday (F), which is equal to a mole of...

In Zinc blende structure (a) zinc ions occupy half of the tetrahedral sites (b) each Zn2- ion is surrounded by six sulphide ions (c) each S2- ion is surrounded by six Zn2+ ions (d) it has free structure

In Zinc blende structure______(a) zinc ions occupy half of the tetrahedral sites(b) each Zn2- ion is surrounded by six sulphide ions(c) each S2- ion is surrounded by six Zn2+ ions(d) it has free site

114 Escherichia coli are on my right index finger. I lisck my finger and accidently eat...

114 Escherichia coli are on my right index finger. I lisck my finger and accidently eat 13 of them. 12 Escherichia coli are on my left thumb, what is the probability that I will eat some when I lick my thumb?

you dip your finger repeatedly into water and make waves. if you dip your finger more...

you dip your finger repeatedly into water and make waves. if you dip your finger more frequently, the wavelength of the waves

Describe the structure of the Communist Party and Government in China’s central power structure. Describe the...

Describe the structure of the Communist Party and Government in China’s central power structure. Describe the evolution of leadership of the Government and Party since 1978.

what is the functional motif of mycobacterium tuberculosis K or mycobacterium tuberculosis in general?

Which of the following is/are protein motif(s) that function as transcription factors for the regulation of...

Which of the following is/are protein motif(s) that function as transcription factors for the regulation of the initiation of transcription? Zinger-finger like protein motifs leucine zipper protein motif helix turn helix protein motif

Which of the following is NOT true of the HTH motif of DNA-binding proteins? Helix 2...

Which of the following is NOT true of the HTH motif of DNA-binding proteins? Helix 2 stabilizes the structural domain with Helix 3 through hydrophobic interactions. Helix 3 situated near the N-terminal of the protein is the DNA recognition helix. Helix 2 is the helix at the beginning of the HTH motif. There are 2 successive alpha helices separated by a sharp beta-turn.

Subjects