Question

what are some common clinical indications for first- line drugs for partial and generalized seizures

Answer 1

Epilepsy is defined as a neurological condition which is marked by sudden recurrent episodes of seizures, loss of consciousness, and sensory disturbances.
Clinical indications for first line drugs for partial and generalized seizures:
1.   Valproic acid –
•   It is indicated as monotherapy and adjunctive therapy in complex partial seizures.
•   Also indicated in patients with complex and simple absense seizures.

2.   Lamotrigine –
•   Indicated in adjunctive therapy for partial seizures.
•   Effective in primary generalized tonic- clonic seizures.

3.   Topiramate-
•   Indicated in partial onset seizures
•   Primary generalized tonic- clonic seizures


Indications of first line drugs for partial seizures:
1.   Carbamazepine-
•   As an anticonvulsant drug.
2.   Phenytoin-
•   In generalized tonic- clonic seizures
•   Complex partial seizures
•   In seizures which occurs during neurosurgery.
3.   Oxcarbazepine-

•   Monotherapy for adults in partial seizures.
•   Adjunctive therapy for children and older.

4.   Ethosuximide-
•   In absense epilepsy
5.   Zonisamide-
•   Adjunctive therapy for partial seizures

6.   Phenobarbital-
•   Seizures in neonates
•   Generalized tonic- clonic seizures
•   Partial seizures
•   Status epilepticus.

7.   Primidone-
•   Effective in psychomotar, and in grand mal seizures.