In: Biology
MAPK pathway, TLR pathway, PPAR gamma signalling
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1.Pick one pathway and determine what process(es) does this pathway regulate and which class does this pathway belong to?
2.How is a signal transmitted from cell surface to nucleus, are second messengers involved, what kind of molecular interactions are involved? (e.g. phosphorylation, dimerization etc.)
##### Answer and Explantion #####
MAPK(Mitogen- Activated protein kinase) pathway
In MAPK pathway this Ras activation activates various second messangers like RAF , MEK and MAP kinase with the help of Ser-Thr phosphorylation, Tyr-Thr phosphorylation and Ser-Thr phosphorylation respectively, and at last this cascade results in the changes in protein activity and ultimately changes in gene expression.
Thanks