Question

Match the following neurotransmitter receptor subtype to the ligand, and properties

Alpha 1, D2, AMPA, CB1, CB2, GABAa, mu opioid, 5HT3, alpha 2, kappa opioid, D1, 5HT1A, GABAb, NMDA

• Binds dopamine with high affinity, producing slow hyperpolarization through decreasing cAMP

• Binds dopamine with low affinity, producing slow repolarization through increasing cAMP

• Binds norepinephrine with low affinity producing slow depolarization through increasing intracellular cAMP

• Binds serotonin, opening ligand gated channel, producing a fast PSP

• Binds serotonin, often found presynaptically acting as auto receptor slowing neurotransmitter release, due to decreased cAMP which closes voltage gated calcium channels

• Ionotropic receptor acting as Cl- channel that increases ion influx in presence of both GABA and depressant drugs like anxiolytics

• Metabotropic receptor producing a slow hyperpolarization when bound to GABA

• Ionotropic receptor ligand gated by glutamate and glycine; also Mg+ blocking channel so require ligands+ simultaneous membrane depolarization to allow Ca++ influx

• Ionotropic receptor ligand gated by glutamate, allowing passage of Na+. This produces most fast EPSPs from glutamate binding

• Binds 2-AG with high affinity, anandamide is a partial agonist, heavily expressed in CNS, found presynaptically, Gi-coupled

• Found on microglia and in periphery on immune cells, Gi-coupled associated with controlling (limiting) cytokine release

• Gi-coupled, ligand activated by dynorphin, found on presynaptic VTA terminals, when activated will decrease DA release from VTA terminals

• Gi-coupled, ligand activated by beta-endorphin, found on presynaptic GABA terminals projecting to VTA, when activated will disinhibit VTA, increasing DA release from VTA

Answer 1

Answer-

according to the given question -

neurotransmitter receptor subtype	properties
Alpha 1	Binds norepinephrine with low affinity producing slow depolarization through increasing intracellular cAMP
D2	Binds dopamine with high affinity, producing slow hyperpolarization through decreasing cAMP
AMPA	Ionotropic receptor ligand gated by glutamate, allowing passage of Na+.
CB1	belongs to Gi/Go-linked GPCR family and inhibit voltage-sensitive calcium channels and adenylyl cyclase and activate potassium channels and MAP kinase
CB2	Found on microglia and in periphery on immune cells,
GABAa	Ionotropic receptor acting as Cl- channel that increases ion influx in presence of both GABA and depressant drugs like anxiolytics
mu opioid	Gi-coupled, ligand activated by beta-endorphin, found on presynaptic GABA terminals projecting to VTA, when activated will disinhibit VTA, increasing DA release from VTA
5HT3	Binds serotonin, opening ligand gated channel, producing a fast PSP
alpha 2	are called adrenoceptors present on the sympathetic nerve terminals that inhibit the release of norepinephrine in a negative feedback mechanism.
kappa opioid	Gi-coupled, ligand activated by dynorphin, found on presynaptic VTA terminals, when activated will decrease DA release from VTA terminals
D1	Binds dopamine with low affinity, producing slow repolarization through increasing cAMP
5HT1A	Binds serotonin, often found presynaptically acting as auto receptor slowing neurotransmitter release, due to decreased cAMP which closes voltage gated calcium channels
GABAb	Metabotropic receptor producing a slow hyperpolarization when bound to GABA
NMDA	onotropic receptor ligand gated by glutamate and glycine; also Mg+ blocking channel so require ligands+ simultaneous membrane depolarization to allow Ca++ influx