Question

Question 20 (Mandatory) (1 point)

Select all of the following which could cause an anemia that is classified as normocytic/ normochromic.

Question 20 options:

	hemoglobin E disease
	hemoglobin SC disease
	beta-thalassemia minor
	aplastic anemia
	decreased red blood cell production
	Hereditary spherocytosis
	liver disease
	renal disease

Question 21 (Mandatory) (1 point)

Which of the following is NOT associated with a spectrin abnormality?

Question 21 options:

	Hereditary stomatocytosis
	Hereditary pyropoikilocytosis
	Hereditary spherocytosis
	Hereditary elliptocytosis

Question 22 (Mandatory) (1 point)

Stomatocytes can be seen in increased numbers on the slide due to poor slide making technique.

Question 22 options:

	True
	False

Question 23 (Mandatory) (1 point)

Abetalipoproteinemia will show which of the following on the peripheral blood smear?

Question 23 options:

	spherocytes
	stomatocytes
	target cells
	acanthocytes

Question 24 (Mandatory) (1 point)

A decrease in all cell lines is referred to as ______________________.

Question 24 options:

	pancytopenia
	panmyelosis
	hyperplasia

Question 25 (Mandatory) (1 point)

Rh null disease is associated with the presence of ____________________.

Question 25 options:

	spherocytes
	stomatocytes
	schistocytes
	acanthocytes

Answer 1

A20) aplastic anemia, renal disease

Normochromic normocytic anemia is the condition in which the blood cells are in normal size and normal in shape and the anemia is present.

Aplastic anemia is the failure of bone marrow. It is the disorder due to attack of white blood cells on bone marrow. The cells is aplastic anemia is normal in size of RBC and normal shape cell.

Renal failure occurs in normochromic and normocytic anemia due to infiltration of RBC cells in glomerulus.

A21)Hereditary stomatocytosis

In Hereditary pyropoikilocytosis, spectrum deficiency is there.

In Hereditary spherocytosis, incorporation and binding spectrin takes place.

In Hereditary elliptocytosis, defect in two spectrins occurs. Alpha spectrin and Beta spectrin. Mutations in genes of alpha spectrin lead to incapability to form alpha beta heterodimers. And mutation in beta spectrin leads to incapability of formation of tetramers.

In Hereditary stomatocytosis, the spectrin molecules will not be defected. It occurs due to osmosis which leads to burst and rupture of cells.

A22)false

In hereditary stomatocytes, increased numbers of stomatocyte cells present in blood smears of alcoholics, liver failure patients etc.

A23)acanthocytes

A24)pancytopenia

A25) acanthocytes