Question

What is a heterozygous B-thalassemia?

Question 10 (Mandatory) (1 point)

A serum ferritin level on a patient with a slight microcytic anemia due to a chronic disease will typically be ___________________.

Question 10 options:

	normal
	decreased
	increased

Question 11 (Mandatory) (1 point)

Another name for a siderotic, or iron, granule is a ________________________.

Question 11 options:

	Howell-Jolly Body
	Heniz Body
	Pappenheimer Body
	Polychromasia

Question 12 (Mandatory) (1 point)

The test which evaluates the binding ability of transferrin is the _____________________ test.

Question 12 options:

	serum ferritin
	serum iron level
	TIBC
	folate level

Question 13 (Mandatory) (1 point)

Most of the iron stored in the body is stored as __________________.

Question 13 options:

	ferric iron
	ferritin
	hemosiderin
	Howell-Jolly bodies

Question 14 (Mandatory) (1 point)

The ferritin level in Sideroblastic anemia would be __________________.

Question 14 options:

	normal
	decreased
	increased

Question 15 (Mandatory) (1 point)

Which of the following would be seen in Sideroblastic Anemia?

Question 15 options:

	an M:E ratio of 6:1
	a negative Prussian Blue
	ringed sideroblasts in the bone marrow
	an RDW of 16.0

Answer 1

Ans )

heterozygous beta thalessemia is a congenital blood dyscrasia which occurs due to lack of beta globin chain in hemoglobin molecule causing microcytic hypochromic anemia . This anemia is mild since the gene coding are hetrozygous .

Q10 decreased .

Microcytic , anemia are generally seen in iron deficiency anemia ,sideroblastic anemia ,anemia of inflammation or chronic fisease amd thalessemia. In these anemias the serum ferritin levels are decreased.

Q11 pappenheimer bodies .

Pappenheimer bofies are charecteristic cells of sideroblastic anemia . Basically these are iron containing granules which precipitate and accumulate ferritin in red blood cells.

Howell jolly bodies are seen in sickle cell anemia which are cell inclusion bodies containing residual nuclear fragments.

Heinz bodies are seen in G 6 Pd deficiency which are again inclusion bodies seen in RBC containing clumps of denatured hemoglobin.

Q12 TIBC

TIBC stands for total iron binding capacity. It ia a test to measure the capacity of blood to bind iron with transferrin which is the transporter plams protein . it indirectly measures transferrin in blood

Q13 ferritin

In human body iron is stoted as ferritin amd hemosiderin in liver ,bon martow and spleen . Rest are carried by circulating RBC.

Q14 increased.

In sideroblastic anemia the laboratory findings are

High serum iron

Increased ferritin levels.

High transferrin levels

Decreased TIBC .

This is because in sideroblastic anemia there is accumulation of iron in cells and unable to be utilised to synthesise hemoglobin .

Q15 a negative prussian blue ringed sideroblast in the bone marrow..

Prussian blue stain is basically ferrocyanide ,when the ferrous in the cells combine with ferrocyanide of the stain it forms ferricferrocyanide which is blue staining around the nucleus wgich are called ringed sideroblasts diagnostic of sideroblastic anemia .

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