1. Phenylketonuria (PKU) is an inherited disorder in which a mutation in a single autosomal gene...

1. Phenylketonuria (PKU) is an inherited disorder in which a mutation in a single autosomal gene leads to inability to break down the amino acid called phenylalanine. Babies born with PKU often have the following symptoms: a musty odor to the skin, hair, and urine; vomiting and diarrhea; irritability; itchy skin, and sensitivity to light. If this condition goes untreated, it can lead to the loss of skills, growth and developmental delays and seizures. The term that best fits with this description of PKU is:

		epistasis
		pleiotropy
		incomplete dominance
		polygenic inheritance

PKU is inherited as an autosomal recessive disorder. Bob and Jan are healthy. Bob is not a carrier of this disorder, but Jan is a carrier of the PKU allele (She is heterozygous.). If they have a child, what is the probability that this child will show the disorder PKU (have the phenotype for PKU)?

4. Huntington disease is inherited as an autosomal dominant disorder with adult onset. Sally has Huntingon disease (She is a heterozygote for this gene). Her partner John does not have Huntington. Suppose Sally and John have 3 children. What is the probability that NONE of their children inherit Huntington Disease?

Solutions

Expert Solution

in 4th questions I'm used binomial theorem to calculate probability...

Because, we have condition in question. Condition is that all 3 children will be normal.

gladiator answered 1 month ago

Next > < Previous

Related Solutions

Phenylketonuria (PKU) is an autosomal recessive disorder in which phenylalanine accumulates in the body, resulting inbrain...

Phenylketonuria (PKU) is an autosomal recessive disorder in which phenylalanine accumulates in the body, resulting inbrain damage, intellectual disabilities, behavioral symptoms, or seizures. PKU affects approximately 1 in 12,000 people living in the United States. What is the frequency of heterozygous carriers of the PKU allele within the U.S. population? (Assume Hardy-Weinberg equilibrium) Group of answer choices 1.80% 0.02% 99.99% 0.90% 0.01%

Phenylketonuria (PKU) is an autosomal recessive metabolic disorder that can result in mental retardation if left...

Phenylketonuria (PKU) is an autosomal recessive metabolic disorder that can result in mental retardation if left untreated. Two normal parents produce a child with PKU. If the recessive PKU allele is ‘n’ and the dominant normal allele is ‘N’, what are the genotypes of both parents? A. Mother is NN and Father is nn B. Mother is Nn and Father is nn C. Mother is nn and Father is Nn D. Mother and Father are both Nn E. Mother and...

4. Phenylketonuria (fen-ul-ke-toe-NU-re-uh), also called PKU, is a rare inherited disorder that causes an amino acid...

4. Phenylketonuria (fen-ul-ke-toe-NU-re-uh), also called PKU, is a rare inherited disorder that causes an amino acid called phenylalanine to build up in your body. PKU is caused by a defect in the gene that helps create the enzyme needed to break down phenylalanine. Without the enzyme necessary to process phenylalanine, a dangerous buildup of this amino acid can develop when a person with PKU eats foods that are high in protein. This can eventually lead to very serious health problems....

Sickle cell anemia is inherited as an autosomal, recessive disorder. Individuals who inherit the mutated gene...

Sickle cell anemia is inherited as an autosomal, recessive disorder. Individuals who inherit the mutated gene from both parents will show symptoms of sickle cell, including a stiffening of the red blood cells when the individual is under conditions with low oxygen levels in the air (e.g. on top of a mountain). This can lead to low red blood cell count (anemia), shortness of breath, fatigue, jaundice, and joint pain. Most critically, the stiffened red blood cells can clog small...

Another disease caused by a mutation in a single gene is Huntington’s disease (HD), an autosomal...

Another disease caused by a mutation in a single gene is Huntington’s disease (HD), an autosomal dominant condition. It is caused by mutations in a gene required for normal nerve cell function. The mutations cause abnormal proteins to be produced which “stick” together and accumulate in nerve cells, eventually interfering with normal cell operations. Suggest two ways you could treat the disease by targeting the translation step for the HD protein and justify why each approach might be effective.

1)Cystic fibrosis an autosomal recessive disorder caused by a single gene, affects the lungs, the pancreas,...

1)Cystic fibrosis an autosomal recessive disorder caused by a single gene, affects the lungs, the pancreas, the digestive system, and other organs, resulting in symptoms ranging from breathing difficulties to recurrent infections. Which of the following terms best describes this? A)incomplete dominance B)multiple alleles C)codominance D)epistasis E)pleiotropy 2)What is one function of a signal peptide during peptide translation? A)to terminate translation of the messenger RNA B)to signal the initiation of transcription C)to bind RNA polymerase to DNA and initiate transcription...

Sickle cell anemia is a recessive disorder caused by a mutation in the hemoglobin A gene....

Sickle cell anemia is a recessive disorder caused by a mutation in the hemoglobin A gene. Persons with the disease have a variety of serious health issues related to fragile and sickling red blood cells including premature death, and infants sometimes die from complications. In regions of central Africa where malaria is endemic, the relative fitnesses for individuals that are homozygous for the wild type hemoglobin allele (HbA), heterozygous (HbAHbS), and homozygous for the sickle cell allele (HbS) are 0.8,...

Assuming Hardy-Weinberg conditions are met: a rare disorder is caused by an autosomal recessive mutation. Calculate...

Assuming Hardy-Weinberg conditions are met: a rare disorder is caused by an autosomal recessive mutation. Calculate the percentage of heterozygous carriers in a population if the disease affects 1 in 15,000 individuals (show your work).

PKU is a rare, fully penetrant, autosomal recessive condition in which an affected individual cannot break...

PKU is a rare, fully penetrant, autosomal recessive condition in which an affected individual cannot break down the amino acid phenylalanine. Neither Brian nor Mary has PKU, and they want to have children. They are concerned because Brian's father has PKU, and while neither of Mary's parents has PKU, her brother has PKU. Use symbols A and a. 1) What is the probability that Mary and Brian's first child will have PKU? Show work. 2) Mary and Brian have a...

1. A severe disease that is inherited as an autosomal recessive trait is more likely to...

1. A severe disease that is inherited as an autosomal recessive trait is more likely to skip generations in a pedigree than an autosomal recessive trait that cuases a harmless phenotypic variant because a) all autosomal recessive traits skip generations b) a person with the harmless variant is less likely to reproduce than a person with the disease c) a person with an autosomal recessive disease is less likely to be well enough to reproduce than a person with a...

Subjects