1. Phenylketonuria (PKU) is an inherited disorder in which a mutation in a single autosomal gene...

1. Phenylketonuria (PKU) is an inherited disorder in which a mutation in a single autosomal gene leads to inability to break down the amino acid called phenylalanine. Babies born with PKU often have the following symptoms: a musty odor to the skin, hair, and urine; vomiting and diarrhea; irritability; itchy skin, and sensitivity to light. If this condition goes untreated, it can lead to the loss of skills, growth and developmental delays and seizures. The term that best fits with this description of PKU is:

		epistasis
		pleiotropy
		incomplete dominance
		polygenic inheritance

2.

PKU is inherited as an autosomal recessive disorder. Bob and Jan are healthy. Bob is not a carrier of this disorder, but Jan is a carrier of the PKU allele (She is heterozygous.). If they have a child, what is the probability that this child will show the disorder PKU (have the phenotype for PKU)?

3.

PKU is inherited as an autosomal recessive disorder. Bob and Jan are healthy. Bob is not a carrier of this disorder, but Jan is a carrier of the PKU allele (She is heterozygous.). If they have a child, what is the probability that this child will show the disorder PKU (have the phenotype for PKU)?

4. Huntington disease is inherited as an autosomal dominant disorder with adult onset. Sally has Huntingon disease (She is a heterozygote for this gene). Her partner John does not have Huntington. Suppose Sally and John have 3 children. What is the probability that NONE of their children inherit Huntington Disease?

Expert Solution

in 4th questions I'm used binomial theorem to calculate probability...

Because, we have condition in question. Condition is that all 3 children will be normal.

gladiator answered 5 months ago

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