Sickle cell anemia is a recessive disorder caused by a mutation in the hemoglobin A gene....

Sickle cell anemia is a recessive disorder caused by a mutation in the hemoglobin A gene. Persons with the disease have a variety of serious health issues related to fragile and sickling red blood cells including premature death, and infants sometimes die from complications. In regions of central Africa where malaria is endemic, the relative fitnesses for individuals that are homozygous for the wild type hemoglobin allele (Hb^A), heterozygous (Hb^AHb^S), and homozygous for the sickle cell allele (Hb^S) are 0.8, 1.0 and 0.1 respectively. The selection coefficient for someone of Central African ancestry who is an Hb^A/Hb^A homozygote born and raised in Chicago would be ____

Expert Solution

Selection co-efficient determines the relative selection strength against any genotype. It is simply determined by subtracting relative fitness value from one.

Mathematically, it can be presented as

Where s represents the genotype for any genotype "XX"

and W is the relative fitness of genotype "XX"

Here, the relative fitness of homozygote HbA/HbA genotype is

Substituting the given values in above equation, we get -

Selection co-efficient of determines that HbA/HbA homozygote will have % difficult time producing offspring than individuals having Selection co-efficient of (here in this case it would be heterozygous (HbAHbS) individuals)

gladiator answered 2 years ago

Sickle cell anemia is a recessive disorder in which hemoglobin loses the ability to effectively deliver...

Sickle cell anemia is a recessive disorder in which hemoglobin loses the ability to effectively deliver oxygen to the tissues. Gene therapy in which hemoglobin gamma-chain is introduced to sickle cell anemia patients seems to be a promising new therapy to correct the disease. Why do you think this is possible, based on your knowledge of the sickle cell mutation and the different hemoglobin polypeptide chains?

Sickle cell anemia is inherited as an autosomal, recessive disorder. Individuals who inherit the mutated gene...

Sickle cell anemia is inherited as an autosomal, recessive disorder. Individuals who inherit the mutated gene from both parents will show symptoms of sickle cell, including a stiffening of the red blood cells when the individual is under conditions with low oxygen levels in the air (e.g. on top of a mountain). This can lead to low red blood cell count (anemia), shortness of breath, fatigue, jaundice, and joint pain. Most critically, the stiffened red blood cells can clog small...

sickle cell anemia is a recessive condition. Two diploid parents, heterozygous for sickle cell anemia produce...

sickle cell anemia is a recessive condition. Two diploid parents, heterozygous for sickle cell anemia produce 5 offspring. What is the probability that the parents have 3 or more children with sickle cell anemia? Using binomial distribution.

What is the most common mutation found in the CFTR gene? c. Sickle cell anemia is...

What is the most common mutation found in the CFTR gene? c. Sickle cell anemia is also inherited as an autosomal recessive trait. What gene is mutated to cause sickle cell anemia? (1 pt) d. Why is it advantageous for a person to be heterozygous for the sickle cell trait? (2 pts)

Beta-thalessemia is caused by mutations in the hemoglobin B gene we discussed along with sickle cell...

Beta-thalessemia is caused by mutations in the hemoglobin B gene we discussed along with sickle cell anemia. There are some anemia-causing mutations that are dominant while other mutations act in a recessive manner. The anemia caused by either type can be debilitating in affected genotypes and would be selected against in areas which do not have malaria. a) Assuming both forms of beta-thalessemia in the affected genotypes show similar fitness relative to unaffected genotypes, which type of allele (recessive or...

abnormal hemoglobin that causes sickle cell is an example of a mutation that is: a)both adaptive...

abnormal hemoglobin that causes sickle cell is an example of a mutation that is: a)both adaptive in areas without malaria and maladaptive in areas with malaria b)adaptive in areas with malaria c)maladaptive in areas with malaria d)adaptive in areas without malaria

Cystic fibrosis is caused by a mutation in a single gene. Homozygotes for this mutant recessive...

Cystic fibrosis is caused by a mutation in a single gene. Homozygotes for this mutant recessive allele (ff) have cystic fibrosis. Within a population, 2% of people have cystic fibrosis. Assuming Hardy-Weinberg equilibrium, the frequency of heterozygotes in the population is 0.24. If inbreeding was common in this population, what would happen to the percentage of people who have cystic fibrosis over time?

Sickle-cell anemia is an autosomal recessive disease, people with the disease have a ss genotype and...

Sickle-cell anemia is an autosomal recessive disease, people with the disease have a ss genotype and people without the disease have a SS genotype. People who have the disease get very ill, but people who have only one copy of the recessive gene are actually protected from getting malaria (Ss heterozygote genotype). Which area of the world is the frequency of sickle cell anemia the highest? Why do you think this is true (related to heterozygote advantage)? We talked about...

what is the difference between sickle cell anemia and sickle cell trait?

QUESTION 15: Sickle cell anemia is usually detected at birth because fetal hemoglobin is affected by...

QUESTION 15: Sickle cell anemia is usually detected at birth because fetal hemoglobin is affected by the genetic mutation. True False QUESTION 16: Pruritic linear lesions that itch more at night that may have more vesicles and papules describes which of the following conditions? Atopic dermatitis Tinea corporis Impetigo Staphylococcal scalded-skin syndrome QUESTION 17: The most common cause of chronic hepatitis in children is: A and B A and C B and C B and D QUESTION 18: Before the...

Question