Question

Create and present a mock CBC given the patient condition and your knowledge of normal reference values (identify and list the appropriate values found on the front cover of your text). Condition: Patient with HDN CBC PARAMETER Create a CBC number with a reasonable and expected result for that condition WBC RBC HGB HCT MCV MCHC RDW MPV PLAT Neutrophils % Lymphs % Monos % Eos % Baso % Neu # Lymph # Mono # Eos # Baso # Significant findings that could be present on the differential smear: WBC: RBC: PLAT:

Answer 1

Hemolytic disease of the newborn, also known as hemolytic disease of the fetus and newborn, HDN, HDFN, or erythroblastosis foetalis, is an alloimmune condition that develops in a fetus at or around birth, when the IgG molecules (one of the five main types of antibodies) produced by the mother pass through the placenta. Among these antibodies are some which attack antigens on the red blood cells in the fetal circulation, breaking down and destroying the cells (hemolysis). The fetus can develop reticulocytosis and anemia. This fetal disease ranges from mild to very severe, and fetal death from heart failure (hydrops fetalis) can occur. When the disease is moderate or severe, many erythroblasts (immature red blood cells) are present in the fetal blood, and so these forms of the disease can be called erythroblastosis fetalis (or erythroblastosis foetalis).

	RESULT	UNIT	REFERENCE INTERVAL
RBC	6.8	×10E6/uL	10.3-13.2
Hemoglobin	14.7	g/dL	12.5-17.0
Hematocrit	40.9	%	36.0-50.0
MCV		fL	69-85
MCH	31.4	pg	27.0-34.0
MCHC	35.9	g/dL	32.0-36.0
RDW	11.7	%	11.7-15.0
Platelets	301	×10E3/uL	140-415
WBC	7.1	×10E3/uL	5.5-16.8
Neutrophills	62	%	40-74
Lymphs	30	%	14-43
Monocytes	5	%	4-13
Eos	2	%	0-7

Basos

1

%

0-3