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In: Nursing

Create a Mock CBC for the following condition Condition: Essential Thrombocythemia CBC PARAMETER PATIENT RESULTS Precursors...

Create a Mock CBC for the following condition

Condition: Essential Thrombocythemia

CBC PARAMETER

PATIENT RESULTS

Precursors

WBC

RBC

HGB

HCT

MCV

MCHC

RDW

MPV

PLAT

Neutrophils %

Lymphs %

Monos %

Eos %

Baso %

Significant findings that could be present on the differential smear:

WBC:

RBC:

PLAT:

Testing to confirm: What are the CD markers and cytogenetic abnormalities? Any relevant cytochemical stains?

Solutions

Expert Solution

Consider a mock case with Thrombocythemia

A 50 year-old woman comes in for a complete blood count (CBC) as part of a routine physical exam.

The results are:

WBC 7.5 K/µL

RBC 4.22 M/µL

Lym 28.7 %

HGB 12.4 g/dL

MID 10.4 %

HCT 38.6 %

Gran 60.9 %

MCV 91.4 fL

MCH 29.3 pg

PLT >>>> K/µL

MCHC 32.0 g/dL

RDW 13.5 %

The platelet count is = 1,068 K/µL (normal is 150-400 K/µL).

MID cells may include less frequently occurring and rare cells correlating to monocytes, eosinophils, basophils, blasts, and other precursor white cells.

Significant peripheral smear findings

Giant,bizzare platelets,platelet clumps,megakaryocytes or their fragment may be observed.Giant plateletes,leucocytosis,Erythrocytosis or slight anemia also present.

CD marker Janus activating kinase 2 (JAK2) V617F is a common mutation in Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs), which include polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF).

The most common Cytogenetic anomalies were trisomy 9 ,abnormal chromosome1 and Trisomy 8.

specific myeloperoxidase cytochemical stain seen in urgent clinical scenarios


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