In: Biology
How would deletion of the Runx3 gene affect T cell's development? Would you expect different results if you knocked out IL7 expression in thymic epithelial cells?
The maturation, survival and proliferation of the T cell population takes place in the Thymus.Various transcription factors regulate the expression of genes through various epigenetic processes along with the help from the numerous cytokines that guides the survival,proliferation,differentiation of specific T cell lineage that plays critical role in acute infection stages.