McArdle Disease (glycogen storage disease 5) is caused by mutations in the phosphorylase enzyme in muscle....

McArdle Disease (glycogen storage disease 5) is caused by mutations in the phosphorylase enzyme in muscle. The symptoms are muscle cramps, pain, and fatigue during strenuous exercise. A) An ischemic exercise test is often used as part of the diagnostic process. This test measures lactate in the blood but is not always specific for McArdle. Explain why lactate might be a good diagnostic measurement for this disease and how its production is regulated in muscle in a normal person versus a McArdle patient. B) A patient is undergoing an ischemic exercise test and is fed 13C glucose prior to the test and then blood is drawn after the test. Explain how the following substrates would be labeled 1) alpha-ketoglutarate, 2) glucose 3) ribose, and 4) alanine. C) in patients with McArdle would you expect electron chain activity to increase, decrease, or remain the same in the muscle cell if the person is at rest? exercising?

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gladiator answered 6 months ago

McArdle Disease (glycogen storage disease 5) is caused by mutations in the phosphorylase enzyme in muscle....

McArdle Disease (glycogen storage disease 5) is caused by mutations in the phosphorylase enzyme in muscle. The symptoms are muscle cramps, pain, and fatigue during strenuous exercise. A) An ischemic exercise test is often used as part of the diagnostic process. This test measures lactate in the blood but is not always specific for McArdle. Explain why lactate might be a good diagnostic measurement for this disease and how its production is regulated in muscle in a normal person versus...

McArdle Disease (glycogen storage disease 5) is caused by mutations in the phosphorylase enzyme in muscle....

McArdle Disease (glycogen storage disease 5) is caused by mutations in the phosphorylase enzyme in muscle. The symptoms are muscle cramps, pain, and fatigue during strenuous exercise. An ischemic exercise test is often used as part of the diagnostic process. This test measures lactate in the blood but is not always specific for McArdle. Explain why lactate might be a good diagnostic measurement for this disease and how its production is regulated in muscle in a normal person versus a...

McArdle Disease (glycogen storage disease 5) is caused by mutations in the phosphorylase enzyme in muscle....

McArdle Disease (glycogen storage disease 5) is caused by mutations in the phosphorylase enzyme in muscle. The symptoms are muscle cramps, pain, and fatigue during strenuous exercise. A patient is undergoing an ischemic exercise test and is fed 13C glucose prior to the test and then blood is drawn after the test. Explain how the following substrates would be labeled 1) alpha-ketoglutarate, 2) glucose 3) ribose, and 4) alanine.

How to draw a regulatory graph of enzyme glycogen phosphorylase with high ATP and low glucose,...

How to draw a regulatory graph of enzyme glycogen phosphorylase with high ATP and low glucose, with axes labeled, 3 plots on the graph and labeled with given regulators and no regulator present, and plots the correct shape

1. Hers disease results from an absence of liver glycogen phosphorylase. Which of the following is...

1. Hers disease results from an absence of liver glycogen phosphorylase. Which of the following is NOT likely to be a symptom of an individual with Hers disease? A. hypolipidaemia B. lethargic between meals C. enlargement of the liver D. hypoglycemic 2. If the concentration of ATP is low, the availability of glucose and acetyl-CoA is high, and no other metabolic demands are made on the cell, what is the most likely fate of oxaloacetate? A. Used for gluconeogenesis B....

3. Glycogen Degradation a) What are the steps in the breakdown of glycogen? b) Glycogen phosphorylase...

3. Glycogen Degradation a) What are the steps in the breakdown of glycogen? b) Glycogen phosphorylase exists in different forms and conformations under different physiological conditions. In a resting muscle, MOST of the phosphorylase will be in which form and which state? c) How do hormones regulate glycogen breakdown?

The nucleophile that is used to free most glucose from glycogen is__________, and Glycogen phosphorylase is...

The nucleophile that is used to free most glucose from glycogen is__________, and Glycogen phosphorylase is active when it is _________________. 1. ATP 2. Tyrosine 3. Serine 4. Inorganic phosphate 5. Water 6. Hydroxide A. Phosphorylated B. Not phosphorylated. C. Denatured.

glycogen storage disease cause changes in metabolism in the item below increased in a patient with...

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Cystic fibrosis is genetic disease caused by mutations in the CFTR gene. The consequence of this...

Cystic fibrosis is genetic disease caused by mutations in the CFTR gene. The consequence of this is production of an abnormal transmembrane protein that is responsible for producing sweat, mucus, and digestive fluids. Explain in depth the correlation between the defective gene and the abnormal protein that is produced. Be sure to mention the process involved in protein production, whether or not those process(s) have occurred, and their end products. Provide details in your explanation and support your answer with...

In muscle tissue, the ratio of phosphorylase a to phosphorylase b determines the rate of conversion...

In muscle tissue, the ratio of phosphorylase a to phosphorylase b determines the rate of conversion of glycogen to glucose 1‑phosphate. Classify how each event affects the rate of glycogen breakdown in isolated muscle tissue. Increased rate Decreased rate No change Answer Bank AMP allosteric binding activates phosphorylase b removal of phosphate groups from phosphorylase a addition of phosphorylase b kinase [ATP] exceeds [AMP] addition of a kinase inhibitor treatment with insulin addition of a phosphatase inhibitor treatment with glucagon

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McArdle Disease (glycogen storage disease 5) is caused by mutations in the phosphorylase enzyme in muscle....

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McArdle Disease (glycogen storage disease 5) is caused by mutations in the phosphorylase enzyme in muscle....

McArdle Disease (glycogen storage disease 5) is caused by mutations in the phosphorylase enzyme in muscle....

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