Question

glycogen storage disease cause changes in metabolism in the item below increased in a patient with non-Gierke disease :

1- glycolysis

choose the larger of the 2 choices if the values are the same write same:

1) - number of ATPs obtained from one glucose in a muscle cell

- number of ATPs obtained from one glucose in a liver cell

- same

2) - number of ATP from one glucose in a liver cell

- number of ATP from 2 GAPs in a muscle cell

- same

Answer 1

In von-Gierke disease, the liver absorbs most of the glucose due to high Glucose-6-phosphate present in the liver which is a product of glycogen breakdown. Hence the glucose levels in liver will be high when compared to the blood glucose levels and hence causes hypoglycemia. Hence due to this the liver will be producing more energy when compared to the muscle cell as the muscle cells cant get enough glucose from the blood.

1. Hence if you see it from the viewpoint of the disease the ATP produced by the liver cells will be more. But because in the options it is stated as one glucose molecule, glycolysis is a universally same process and hence the number of ATP produced will be the same in both the liver and muscle cell. Hence the answer is: same.

2. The number of ATP produced from one glucose in liver cell is 2ATP during glycolysis whereas the number of ATP produced from two moles of Glyceraldehyde-3-phosphate is 4ATP. Hence the correct answer is: number of ATP from 2 GAPs in a muscle cell.

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