QUESTION 3 1. Describe the normal cellular functions of tumor suppressor genes and explain their roles...

QUESTION 3

1. Describe the normal cellular functions of tumor suppressor genes and explain their roles in cancer. List all possible mechanisms by which tumor suppressor genes are inactivated and explain. Explain why loss-of-heterozygosity of a particular chromosome/chromosomal region in tumor DNA suggests the existence of a tumor suppressor gene in that region.

2. Why is pRB function compromised in human tumors through mutations of its encoding gene while the genes encoding its two cousins, p170 and p130, have virtually never been found to suffer mutations in the genomes of cancer cells?

Expert Solution

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gladiator answered 6 months ago

Describe the normal cellular functions of tumor suppressor genes and explain their roles in cancer. List...

Describe the normal cellular functions of tumor suppressor genes and explain their roles in cancer. List all possible mechanisms by which tumor suppressor genes are inactivated and explain. Explain why loss-of-heterozygosity of a particular chromosome/chromosomal region in tumor DNA suggests the existence of a tumor suppressor gene in that region. Please type answer, hard to read handwriting on written responses.

Question: Is there a difference between oncogenes and tumor suppressor genes? 1. Yes, oncogenes are genes...

Question: Is there a difference between oncogenes and tumor suppressor genes? 1. Yes, oncogenes are genes that can cause cancer when they become mutated to become proto-oncogenes, whereas tumor suppressor genes play no role in cancer. 2. Yes, oncogenes prevent cancer from forming unless they are mutated to become proto-oncogenes, whereas tumor suppressor genes stimulate the formation of cancer even in the absence of mutation. 3. No, oncogenes and tumor suppressor genes both stimulate the development of cancer, even in...

Question 1: You have been studying various oncogenes and tumor suppressor genes in tumor cell lines...

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Describe the role of proto-oncogenes/oncogenes OR tumor suppressor genes in the development of cancer. RNA processing...

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Considering the normal functions of the liver, describe how 3 of the functions would present in...

Considering the normal functions of the liver, describe how 3 of the functions would present in an abnormal manner

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