1. Which statement below is an accurate description of how the products of tumor-suppressor genes exert...

1. Which statement below is an accurate description of how the products of tumor-suppressor genes exert their effect?

A. When not mutated, most act as restrictors of cell proliferation.

B. When not mutated, most act as promoters of cell proliferation.

C. If normal tumor suppressor gene products are present, uncontrolled cell growth is the result.

D. A and C

2. __________ is an approach that tries to get the immune system more involved in the fight against cancer.

A. Gene therapy

B. Inhibition of cancer-promoting proteins

C. Immunotherapy

D. Inhibition of angiogenesis

Explain why pleasee!

Expert Solution

1. The tumor-suppressor genes are the genes that keep the cell growth in check. They stop the tumor causing genes or in other words the cell cycle initiating genes in check. By doing so they stop the uncontrolled cell division thereby suppressing the genes responsible for causing of tumor. p53 is a tumor suppressor gene and suppresses various cell cycle pathways when in normal condition. But it p53 was mutated then the cell cycle pathway will get activated and uncontrolled cell divisions will take place producing a tumor. Hence the correct answer from the given options is: A. When not mutated, most act as restrictors of cell proliferation.

2. C.Immunotherapy is an approach that tries to get the immune system more involved in the fight against cancer. In immunotherapy, the body's immune system response is heightened to counter attack the cancer causing agents and eliminate them. The other options mentioned such as gene therapy works by editing the cancer causing gene in-vitro and then reintroducing this gene into the host cell. The inhibition of cancer promoting proteins is done by the chemotherapy or radiation and this doesnt involve much of the bodys immune system reaction. The inhibition of angiogenesis is the inhibiting the supply of blood to the cancer cells thereby decreasing the amount of nutrient flow to cancer cells and hence starving the cancer cells. This also doesnt activate the immune system.

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gladiator answered 2 years ago

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