Question

How do regulatory enzymes, secondary messengers, and major hormones influence the process of lipolysis? What other various methods does white adipose tissue exert influence on metabolic and pathophysiological processes?

Answer 1

The catabolism of triacylglycerols yields glycerol
and fatty acids, a process termed lipolysis. The
major site of lipolysis is adipose tissue, and the
glycerol and fatty acids then enter the blood. Free fatty acids (FFAs) are liberated from lipoporteins by lipoprotein lipase(LPL) and enter the adipocyte, where they are reassembled into triglycerides by esterifying them onto glycerol. Human fat tissue contains about 87% lipids.There is a constant flux of FFAs entering and leaving adipose tissue. The net direction of this flux is controlled by insulin and leptin.when insulin is low can FFA leave adipose tissue In humans, lipolysis (hydrolysis of triglycerides into free fatty acids) is controlled through the balanced control of lipolytic B-adrenergic receptors. Protein and peptide hormones cannot penetrate plasmamembranes of tissue cells so they require assistance of 1. hormone receptor on plasma membrane 2. the signal transducer (G protein) and 3. the effector enzyme (adenylate cyclase)