I have been told that there is some conflict within the scientific community as to how...

I have been told that there is some conflict within the scientific community as to how abnormalities in the IL23 gene can lead to Crohns disease. Can someone please describe any conflicting theories or alternative pathways that go from defective IL23 gene to Crohns disease?

Solutions

Expert Solution

Crohns disease is a condition wherein the digestive tract gets inflammed, also known as one of inflammatory bowel disease.IL23 cytokine has been found to be elevated in pateints with Crohns disease.Many treatment paths to treat Crohns disease target IL23, specifically the IL23 p19 subunit.It also has an IL12p40 subunit also shared by IL12 cytokine, thusmany treatments for the disease target both IL23 and IL12.IL23 mediates the intestinal inflammation path via its receptor IL23R, which also shares a subunit with IL12 receptor, the IL12beta1 subunit and another novel IL23R subunit. IL23 has been shown to initate the inflammatory cascade via production of IL-17 and TNFgamma.

There has been proof of differential role of IL12 in the inflammatory response in Crohns disease in absence of IL23.

Variants and various SNPs(Single Nucelotide Polymorphisms) in the IL23R have been also linked with susceptibility to Crohns disease.

gladiator answered 1 year ago

Next > < Previous

Related Solutions

EXERCISE IV - Conflict Resolution In our society, we have always been told that compromise is...

EXERCISE IV - Conflict Resolution In our society, we have always been told that compromise is a good thing. Whetten and Cameron challenge this belief by saying collaboration is the best answer. They do not ask you to believe that because they say so. Instead they suggest that compromise solutions to major problems carry the weakness of being unsustainable....the solution will not stand the test of time.....after a period of time the problem reappears. Have you experienced this type of...

a) The percentage of adults who have at some point in their life been told that...

a) The percentage of adults who have at some point in their life been told that they have hypertension is 23.53%. In a sample of 10 adults, let X be the number who have been told that they have hypertension. Consider the following probability distribution for X. x P(x) 0 ? 1 ? 2 ? 3 ? 4 ? 5 a 6 0.0122 7 0.0021 8 0.0002 9 0.0000 10 0.0000 Find the missing entry that is labelled as 'a'....

You have been told that some of the variances that are generally calculated are not very...

You have been told that some of the variances that are generally calculated are not very useful. Explain the meaning and value of each of these variances. With meaning, this includes what it measures. Min 3 sentences per variance. Direct materials price variance Direct labor price variance Variable manufacturing overhead efficiency variance Fixed manufacturing overhead volume variance

I have been told that a quick way to get the Feynman rules from a Lagrangian...

I have been told that a quick way to get the Feynman rules from a Lagrangian is to take an interaction term, forget about the fields and multiply an i. This works perfectly for example for QED but I wonder if there is an analogous non rigorous quick way to obtain the feynman rules of for example non abelian gauge theories.

Despite being universally accepted within the scientific community for over 150 years, the theory of evolution...

Despite being universally accepted within the scientific community for over 150 years, the theory of evolution remains poorly understood by the public in some cases. Imagine that you are conversing with a friend who has some misconceptions about evolution. describe how you would explain evolution in brief, simple terms to a non-scientist. What does “evolution” mean? How does it work? What is one concrete example that you feel provides strong empirical evidence of evolution.

Within your community, there has been a large increase in teenage smoking, and community leaders are...

Within your community, there has been a large increase in teenage smoking, and community leaders are developing a plan to decrease the incidence of smoking. To help them, you will: A) Develop a research question to address the problem. B) Determine what kind of study should be undertaken. C) Design a study to decrease the incidence of smoking in teenagers.

I. Identify an organization you have joined within your community/school, write the name of the organization,...

I. Identify an organization you have joined within your community/school, write the name of the organization, goals and objectives, duties of members and current activities/projects of the organization. II. 1. In your own words, differentiate diffusion from osmosis. 2. How does the renal system maintain the body’s homeostasis? 3. Enumerate the IV fluids and classify them according to their tonicity.

1. A new virus of lobster has been found, and you have been told that they...

1. A new virus of lobster has been found, and you have been told that they suspect it is a herpesviruses. Which of these would NOT be expected if it really is a herpesviruses? A. It is a naked virus B. It has a double stranded DNA genome C. It has icosahedral capsids D. It has a large DNA genome 2. A woman comes in for a prenatal check up and casually mentions she brought her three year old with...

Suppose that some data have been collected on the returns on a portfolio i and on...

Suppose that some data have been collected on the returns on a portfolio i and on the excess returns on a market index as shown in the following table. What is the OLS estimator for βi ? year Portfolio return Market return 2015 2.8 1.5 2016 3.9 4.3 2017 4.6 5.6 2018 1.6 2.1 A. 0.51 B. 0.60 C. 0.32 D. 1.23

How does the community health nurse recognize bias, stereotypes, and implicit bias within the community? How...

How does the community health nurse recognize bias, stereotypes, and implicit bias within the community? How should the nurse address these concepts to ensure health promotion activities are culturally competent? Propose strategies that you can employ to reduce cultural dissonance and bias to deliver culturally competent care. Include an evidence-based article that address the cultural issue.

Subjects