Question

Please include tips and tricks for synthesis reactions in organic chemistry

Answer 1

the below information i have given little clear with example generally There’s a lot of different ways to go about learning how to do synthesis – and I’ll have a lot more to say about that in future posts – but today’s post addresses one of the simplest and most effective ways of learning how to do it.

It’s all about maps.

Maps are easy to understand – they make distances and relationships concrete.

suppose look at a reaction map for ketones

If you look at all these reactions – forward and backward – you can link functional groups to each other through these types of reactions.

You can build reaction maps for other functional groups. Here’s one for secondary alcohols.

The more reactions you learn, you’ll see that some types of functional groups (like ketones) are very “busy” – like central hubs, there’s lots of reactions that link to them (and link from them). On the other hand, other functional groups are a little like Laredo: dusty, one-horse towns in the middle of nowhere. (Of all the functional groups you learn about, ethers fall into this category the best).

Let’s go back to our problem. If you identify the functional groups involved, it can help you to identify what types of reactions are possible for getting you from your starting point to the destination.

We’re asked to go from an aldehyde to a tertiary alcohol.

Go back to the reaction map. Look for the tertiary alcohol as a product. Then work backwards. How do you get there? One way is from a ketone, in a Grignard reaction. Then think backwards from there – how to get there? One way is to oxidize a secondary alcohol. And if you trace back secondary alcohols, you can get there from the aldehyde and a Grignard reaction.

Once you know what reactions to use, it’s much easier to design your synthesis. Here, the problem is identifying what alkyl groups to use in each of the two Grignard reactions.