Describe in detail an example of a disease that is caused by an imbalance of estrogen...

Describe in detail an example of a disease that is caused by an imbalance of estrogen signaling.

Expert Solution

?Describe in detail an example of a disease that is caused by an imbalance of estrogen signaling.

Due to imbalances in estrogen signaling, there would be a problem in uptake of glucose as well as disturbances in expenditure of energy. This hypothesis has been put forward, referred to as the reaves hypothesis, wher, there had been an association between the insulin resistance in cells, along with a hyperinsulinemia. This is because there would be a problem in the se-xual steroids in the females. With a decrease in estrogen from the ovaries, there would be a decrease in the uptake of glucose. This is because, in maintenance of glucose levels within the cells, there would be estradiol playing a significant role. With problems in estrogen receptor, there would be dysmetabolism leading to diabetes type 2. Estrogen receptor Alpha as well as estrogen receptor beta help as estrogen binding would activate the the nucleus, acting as transcriptional modulators in promotion of target genes.

Also, if there is hyperestrogenism,, it may lead to a disruption in glucose uptake leading to insulin resistance in the obese women.

gladiator answered 2 years ago

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