In: Biology
Golgi appratus does the targeting of all secreatory protein to their final destination. So any mutation in Golgi aparatus leads to severe nonfunctionality of different organ including neuron which leads to Parkinson disease and Alzimer disease.
In Alzimer disease it's been notice that the accumulation of harmful amyloid protein which cause ultimetly plaque on neuron or degrade the neuron cells and hence leads to loss of memory and other neurological diseases.
While in case of Parkinson's disease there is mutation in several genes which regulates antrigrade and reterigrade movt and hence protein distribution is not there and leads to accumulation of protein alpha sunuclein which affectes brain. Due to which certain part of brain which regulate movement become non functional.
Further Achondrgenesis is s disease in which there is short limb or bone formation takes place in case of mammals as microtubules formation is become defect that leads to defect in vesicle formation and hence transport of proteins. This leads to defective cartilage and bone formation.
Hopeclear..Thanks..