Question

Explain in detail a disease associated with 3-hydroxy-3-methyl-glutaryl-CoA reductase. Describe the symptoms of the disease

Answer 1

Atherosclerosis is a disease linked with 3-hydroxy-3-methyl-glutaryl-CoA reductase. Atherosclerosis is caused because of the forming of plaques that are the hardening and narrowing of coronary arteries. Arteries are blood vessels that carry oxygen-rich blood to the heart and other parts of our body.

Plaque is made up of fat, cholesterol, calcium, and other substances found in the blood. Over time, plaque hardens and narrows your arteries. This limits the flow of oxygen-rich blood to your organs and other parts of your body.

Atherosclerosis can lead to serious problems, including heart attack, stroke, or even death.

If plaque narrows or blocks these arteries causing a disease called ischemic heart disease, a common symptom is an angina. Angina is chest pain or discomfort that occurs when your heart muscle doesn't get enough oxygen-rich blood.

Angina could feel like pressure or squeezing in your chest. The pain radiates to shoulders, arms, neck, jaw, or back. Angina pain may sometimes be similar to indigestion. The pain tends to get worse with activity and go away with rest. Emotional stress also can trigger pain.

Other symptoms of ischemic heart disease are shortness of breath and arrhythmias. Arrhythmias are problems with the rate or rhythm of the heartbeat.

Plaque also can form in the heart's smallest arteries. This disease is called coronary microvascular disease (MVD). Symptoms of coronary MVD include angina, shortness of breath, sleep problems, fatigue (tiredness), and lack of energy.