What are the levels of protein structure for the Cystic Fibrosis Transmembrane conductance regulator? Including primary,...

What are the levels of protein structure for the Cystic Fibrosis Transmembrane conductance regulator? Including primary, secondary, tertiary, and quaternary.

Expert Solution

gladiator answered 2 years ago

Cystic Fibrosis Transmembrane conductance Regulator (CFTR) is an ABC transporter that allows passage of chloride ions...

Cystic Fibrosis Transmembrane conductance Regulator (CFTR) is an ABC transporter that allows passage of chloride ions across the plasma membranes of epithelial cells. Mutations in the gene for CSTR cause a decrease in fluid and salt secretion by CFTR and result in cystic fibrosis. In 70% cases of the disease, the mutation is a deletion of a Phe residue at position 508. The mutant protein folds incorrectly, which interferes with its insertion in the plasma membrane, and as a consequence,...

Cystic fibrosis is an autosomal recessive genetic disorder resulting from the absence of a functional transmembrane...

Cystic fibrosis is an autosomal recessive genetic disorder resulting from the absence of a functional transmembrane conductance regulator (CFTR) protein. A woman whose older sister has a son with the disorder is concerned that she will also have a child with cystic fibrosis. The woman’s husband is healthy but he had a paternal uncle who died of cystic fibrosis as a teenager. A. Based on the information given above, draw a pedigree for the couple and the extended families...

Description of cystic fibrosis? What has changed in cystic fibrosis to allow it to cause a...

Description of cystic fibrosis? What has changed in cystic fibrosis to allow it to cause a genetic disorder? Explain how this differs from the gene's normal function.Is it possible for parents to not have the disorder, but pass it on to their children? What kind of dominance pattern does cystic fibrosis show? What problem(s) is/are caused to a person who inherits the cystic fibrosis gene? Is this typically inherited from the mother or the father? Describe an experiment that you...

Why does the primary structure impact all levels of protein structure? What is unique about the...

Why does the primary structure impact all levels of protein structure? What is unique about the peptide bond that directly impacts protein structure? What intermolecular forces stabilize protein structure? Consider protein denaturation, what environmental forces can cause a protein to lose its structure? What types of interactions are they disrupting? Many proteins require chaperones to properly fold. How do chaperones help proteins fold? What potential problems might arise from a misfolded protein? (An example from the text may be useful...

What is cystic fibrosis? How does cystic fibrosis work to enhance survival for heterozygous individuals?

what is the etiology and pathogenesis of cystic fibrosis

levels of protein structure

Cystic Fibrosis is a disease caused by a defect in a Chloride ion transport channel protein....

Cystic Fibrosis is a disease caused by a defect in a Chloride ion transport channel protein. The channel performs a critical function in the lungs; thus, disease sufferers have trouble clearing mucous from their lungs, leaving them susceptible to opportunistic infections. Discuss how this protein may function (normally) in the lung & hypothesize on possible treatment schemes.

1. In cystic fibrosis one amino acid is missing in the CFTR protein. Explain why this...

1. In cystic fibrosis one amino acid is missing in the CFTR protein. Explain why this mutant protein will not end up in the plasma membrane. (You may need to investigate the normal function of this CFTR gene) 2. Why might a mutation in the DNA NOT lead to an abnormally functioning protein? 3. Describe one genetic disorder in which a gene is mutated and leads to abnormal protein folding ( other than Huntington’s). In “your disorder”, name the gene...

Question 1. Cystic Fibrosis (CF) is an example of a protein mis-folding disorder since most of...

Question 1. Cystic Fibrosis (CF) is an example of a protein mis-folding disorder since most of the mutations associated with CF lead to the improper folding and processing of the plasma membrane-localized Cystic Fibrosis Transmembrane Conductance Regulator ion channel (CFTR). The CFTR protein initially enters the endomembrane system through the process of co-translational translocation into the endoplasmic reticulum (ER) and is inserted as a Type IV membrane protein. N-linked glycosylation of the CFTR protein then takes place in the ER...

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