Cystic fibrosis is an autosomal recessive genetic disorder resulting from the absence of a functional transmembrane...

Cystic fibrosis is an autosomal recessive genetic disorder resulting from the absence of a functional transmembrane conductance regulator (CFTR) protein. A woman whose older sister has a son with the disorder is concerned that she will also have a child with cystic fibrosis. The woman’s husband is healthy but he had a paternal uncle who died of cystic fibrosis as a teenager.

A. Based on the information given above, draw a pedigree for the couple and the extended families described above. Here is some additional information about both families: Woman - has two siblings, the sister with the affected son and a younger brother who does not have children. Neither of the woman’s parents or her siblings have the disease. The sister has a healthy daughter and the sister’s husband is also healthy. Husband – has one unaffected older brother who has two unaffected daughters. Both of his parents are unaffected. His father’s older brother is the uncle that died from cystic fibrosis. Include as many generations and individuals as you can in your pedigree. For simplicity, assume that individuals homozygous for a non-functional CFTR protein do not live long enough to reproduce.

B. What is the probability that this woman and her husband will have a child with cystic fibrosis?

Assume that only one of the woman’s parents is a carrier of the recessive allele for cystic fibrosis. Also assume that her husband’s mother has two normal alleles of the CFTR gene.

Solutions

Expert Solution

Ans A) the Pedigree of given family from the given information is as below :

Alleles = F = Dominant = normal or unaffected ; f = recessive = affected in ff (Homozygous Recessive Condition).

Ans B) Probability that this woman and her husband will have a child with Cystic Fibrosis ( ff). In the question the information about their parents Genotype is also given as either of woman's Parents have a recessive allele (f) and the husband's mother is Homozygous for Dominant allele of CFTR gene = FF. The husband's Father could be FF or Ff as he is healthy and has an elder brother who died of Cystic Fibrosis. So, he can be FF or Ff and hence with wife FF he can have child with Genotypes FF or FF and Ff. We have to find the Probability of having affected child of woman and husband then husband will be a carreir by Probability 1/2 as ( 1 = Ff ; 2 = FF + Ff).

Mother carrier by = 2/4 or 1/2

Father = 1/2

Child can be affected by = 1/4

Probability of affected child = 2/4 * 1/2 * 1/4

= 1/16.

gladiator answered 1 year ago

Next > < Previous

Related Solutions

Exercise 6.2 worksheet - MONOHYBRID PRACTICE PROBLEMS 1. Cystic fibrosis is an autosomal recessive genetic disorder....

Exercise 6.2 worksheet - MONOHYBRID PRACTICE PROBLEMS 1. Cystic fibrosis is an autosomal recessive genetic disorder. Ron is homozygous dominant (FF) and Nancy is a carrier (Ff ) of cystic fibrosis. Use a Punnett square to predict the genotypic and phenotypic ratios of their offspring who are normal, normal carriers, and affected. Show all your work. Assign symbols for each allele. Parents (P): Male ♂ = Female ♀ = Key Punnett Square: First Generation (F1) Genotypic Ratio: Phenotypic Ratio: 2....

1)Cystic fibrosis an autosomal recessive disorder caused by a single gene, affects the lungs, the pancreas,...

1)Cystic fibrosis an autosomal recessive disorder caused by a single gene, affects the lungs, the pancreas, the digestive system, and other organs, resulting in symptoms ranging from breathing difficulties to recurrent infections. Which of the following terms best describes this? A)incomplete dominance B)multiple alleles C)codominance D)epistasis E)pleiotropy 2)What is one function of a signal peptide during peptide translation? A)to terminate translation of the messenger RNA B)to signal the initiation of transcription C)to bind RNA polymerase to DNA and initiate transcription...

Cystic fibrosis is an autosomal recessive disorder (c). Consider a cross between two heterozygote parents. Using...

Cystic fibrosis is an autosomal recessive disorder (c). Consider a cross between two heterozygote parents. Using a Punnett square, demonstrate what percentage of their offspring would have the disease? What are the genotypic ratios of all the possible outcomes from this cross?

Question 15 - Cystic fibrosis is transmitted as a(n): X-linked recessive gene autosomal recessive gene autosomal...

Question 15 - Cystic fibrosis is transmitted as a(n): X-linked recessive gene autosomal recessive gene autosomal dominant gene chromosomal defect

Cystic fibrosis is a recessive disorder. If a child comes from two heterozygous parents, what is...

Cystic fibrosis is a recessive disorder. If a child comes from two heterozygous parents, what is the chance that the child will have it too? 25% 75% 50% 100%

Cystic fibrosis (CF) is a genetic disorder that affects mostly the lungs, but also the pancreas,...

Cystic fibrosis (CF) is a genetic disorder that affects mostly the lungs, but also the pancreas, liver, kidneys, and intestine. CF is inherited in an autosomal recessive manner with simple Mendelian inheritance. It is caused by the presence of mutations in the gene for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. A normal couple intends to have children but consult a genetic counselor because the man has a sister with CF and the woman has a brother with CF....

Cystic fibrosis (CF) is a genetic disorder that affects mostly the lungs, but also the pancreas,...

Cystic fibrosis (CF) is caused by a genetic mutation resulting in defective proteins in secretory cells,...

Cystic fibrosis (CF) is caused by a genetic mutation resulting in defective proteins in secretory cells, mainly in the epithelial lining of the respiratory tract. The one in every 2,000 Caucasian babies who has the disease is homozygous for the recessive mutant. Although medical treatment is becoming more effective, in the past, most children with CF died before their teens. About 20 Caucasian in 2,000 are carriers of the trait, having one mutant and one normal allele, but they do...

Phenylketonuria (PKU) is an autosomal recessive disorder in which phenylalanine accumulates in the body, resulting inbrain...

Phenylketonuria (PKU) is an autosomal recessive disorder in which phenylalanine accumulates in the body, resulting inbrain damage, intellectual disabilities, behavioral symptoms, or seizures. PKU affects approximately 1 in 12,000 people living in the United States. What is the frequency of heterozygous carriers of the PKU allele within the U.S. population? (Assume Hardy-Weinberg equilibrium) Group of answer choices 1.80% 0.02% 99.99% 0.90% 0.01%

Cystic fibrosis is a genetic disorder where mutated alleles (point or gene mutations) produce a defective...

Cystic fibrosis is a genetic disorder where mutated alleles (point or gene mutations) produce a defective transport protein that results in organs producing a sticky mucus. Discuss how an individual with cystic fibrosis would make the abnormal protein. Your answer should include all the molecules and all the processes involved in going from genotype to phenotype.

Subjects