Question

Description of cystic fibrosis?

What has changed in cystic fibrosis to allow it to cause a genetic disorder? Explain how this differs from the gene's normal function.Is it possible for parents to not have the disorder, but pass it on to their children?

What kind of dominance pattern does cystic fibrosis show?

What problem(s) is/are caused to a person who inherits the cystic fibrosis gene? Is this typically inherited from the mother or the father?

Describe an experiment that you could use to determine if a new drug is effective at treating cystic fibrosis. Be sure to mention the independent, dependent and control variables.

How you could use the scientific method to draw conclusions about cystic fibrosis or to treat this disorder?

Answer 1

• Cystic fibrosis (CF) is a hereditary disorder that involves serious damage to the body's lungs, digestive system and other organs. The cells that contain mucus, sweat and digestive juices are affected by cyst fibrosis. Those secreted fluids are generally sticky and thin. Many common symptoms may include infections with the sinus, poor growth, fatty stool, finger and toe clubbing and infertility in most males.
• CF is inherited autosomally, recessively. It is identified by the growth of mutations for cystic fibrosis transmembrane conducctance regulator (CFTR) protein across both sets of genes. All with one working copy are carriers and relatively safe. CFTR is involved in the production of blood, digestive fluids and mucus. When the CFTR is not functioning, secretions that are normally thin become dense respectively.
• Each individual has two copies of the transmembrane conductance regulator gene for cystic fibrosis. In order to have cystic fibrosis, a patient should obtain two versions of the CFTR gene which carry mutations one copy of each parent.
• Cystic fibrosis is inherited in a recessive, autosomal pattern. It ensures one will inherit two copies of the damaging cystic fibrosis allele to have mucous fibrosis. Having a single copy makes somebody a carrier, but since the standard allele for this gene is dominant over the gene of cystic fibrosis, individuals normally can not have cystic fibrosis.
• Mutations in this Gene cause the CFTR protein to malfunction or not be managed to make ever again, that actually results in thick mucus build-up, and this in turn causes to prolonged lung infections, pancreatic damage and serious health problems in many other organs.
• Cystic fibrosis (CF) is a hereditary disorder that develops when both parents transmit a CF gene to their offspring. The child will only be diagnosed with CF if each parent inherits one CF gene. An individual who has only one gene for CF is called a carrier for CF.
• Trikafta has been the first combination drug therapy effective for treating patients with one of the most prevalent condition of cystic fibrosis. It allows to work more effectively with the damaged protein which is produced by the CFTR mutation. Its acceptance is derived from the results of multiple clinical trials in which several health professionals actively engage.
• Cystic fibrosis (CF) is a heterogeneous multi-organ condition caused by CFTR gene mutations due to misfolding (and other defects) and subsequent CFTR protein dysfunction, including its major pathological implications on respiratory function. Most mutations cause a serious CF phenotype and individuals with this state would also needs a variety of medical treatments and therapies throughout their lives to resolve their illnesses. Gene therapy or gene replacement is a process where a new, compatible version of the CFTR gene is inserted into a person's body cells. Although the mutated copies of the CFTR gene would be present, the possession of the correct version would allow cells the capacity to produce normal CFTR proteins.