Describe natural antibiotic resistance in Gram-negative bacteria and how people fuel the fire of antibiotic resistance.

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Gram-negative bacteria acquire antibiotic resistance as a result of natural selection. The Genetic variations which cause mutations help their survival in the presence of antimicrobial agents causing an.tibiotic resistance

The Gram-negative outer membrane is an important barrier that provides protection against antibiotics

Mechanisms of Gram-negative antibiotic resistance are

acquisition of enzymes that modify or destroy antibiotics like aminoglycoside-modifying enzymes and and carbapenemases

acquisition of enzymes that alter bacterial antibiotic targets.

acquisition of mutations in bacterial targets such as topoisomerases, ribosomes.

Gram-negative bacteria can acquire resistance to important classes of antibiotics

the ways people fuel the antibiotic resistance are

Over-prescription of antibiotics
Absence of new antibiotics discovery
Overuse of antibiotics in livestock and aquaculture.
Patients not completing the entire medicine course which allows bacteria to develop resistance to drugs.
Poor infection control.
improper hygiene and sanitation

gladiator answered 1 year ago

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