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In: Biology

Describe natural antibiotic resistance in Gram-negative bacteria and how people fuel the fire of antibiotic resistance.

Describe natural antibiotic resistance in Gram-negative bacteria and how people fuel the fire of antibiotic resistance.

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ans

Gram-negative bacteria acquire antibiotic resistance as a result of natural selection. The Genetic variations which cause mutations help their survival in the presence of antimicrobial agents causing an.tibiotic resistance

The Gram-negative outer membrane is an important barrier that provides protection against antibiotics

Mechanisms of Gram-negative antibiotic resistance are

acquisition of enzymes that modify or destroy antibiotics like aminoglycoside-modifying enzymes and and carbapenemases

acquisition of enzymes that alter bacterial antibiotic targets.

  acquisition of mutations in bacterial targets such as topoisomerases, ribosomes.

Gram-negative bacteria can acquire resistance to important classes of antibiotics

the ways people fuel the antibiotic resistance are

  • Over-prescription of antibiotics
  • Absence of new antibiotics discovery
  • Overuse of antibiotics in livestock and aquaculture.
  • Patients not completing the entire medicine course which allows bacteria to develop resistance to drugs.
  • Poor infection control.
  • improper hygiene and sanitation

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