The protein Ras is overactive in numerous cancers; its function requires the addition of a farnesyl...

The protein Ras is overactive in numerous cancers; its function requires the addition of a farnesyl (C15) group. What is the role of the farnesyl group in Ras activation and downstream effects? Explain how farnesyl diphosphate is synthesized, starting from acetyl-CoA and naming intermediates, enzymes and cofactors. What effect would statins have on the activity of Ras?

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gladiator answered 2 years ago

If the GTPase function of Ras is destroyed, Ras will always be on/activated. This causes increased...

If the GTPase function of Ras is destroyed, Ras will always be on/activated. This causes increased Cyclin D and S phase genes expression by transcription factor E2F. Describe how this activation of Ras causes this increased expression of both Cyclin D and S phase genes by explaining the role/function of the following: Raf, MEK, ERK Myc Cyclin D/Cdk4 or Cdk 6 Rb E2F also indicate if any of the above are a kinase or transcription factor

The protein mTOR is observed to be overactive in many cancers. Explain why this is the...

The protein mTOR is observed to be overactive in many cancers. Explain why this is the case. Name three events that cause mTORC1 to become activated, three events that cause mTORC1 to become inactivated, and explain the molecular signals that lead to each outcome.

Which is common feature shared between the GG-subunit of a G-protein complex and the c-ras protein?...

Which is common feature shared between the GG-subunit of a G-protein complex and the c-ras protein? Select one: a. intrinsic GTPase activity b. membrane associated protein c. signal transduction d. All of these e. None of these.

under what condition GTPase-activating protein (GAP) Switches off the RAS-MAPK signaling pathway during EGFR-mediated Ras-activation?

The blood contains numerous components, each with its own function: Choose a component of the blood,...

The blood contains numerous components, each with its own function: Choose a component of the blood, and describe its role in the body. Your response should be a minimum of 100 words, with in-text citations and references. In addition, please respond to at least two other students to add information, present another point of view, or ask questions.

28) Ras is a __, which can cancer development when activated constitutively. A) Adapter protein...

28) Ras is a ________, which can ______ cancer development when activated constitutively. A) Adapter protein of the insulin signaling pathway, promote B) Monomeric G-protein, suppress C) Heterotrimeric G-protein, promote D) Monomeric G-protein, promote 29) Which of the following is not an event happened during prophase? A) The nuclear lamina is disassembled by depolymerization of the lamin filaments. B) Fragmentation of Golgi complex and ER. C) Chromosomal material condenses to form compact mitotic chromosomes D) Chromosomal microtubules attach to kinetochores....

1. Ras is a __, which can cancer development when activated constitutively. a. adaptor protein...

1. Ras is a ________, which can ______ cancer development when activated constitutively. a. adaptor protein of the insulin signaling pathway, promote b. monomeric G protein, suppress c. heterotrimeric G protein, promote d. monomeric G protein, promote 2. The _____ kinase is essential in yeast for adding an inhibitory phosphate group to ____ when it is bound to a cyclin, which prevents the cell from entering mitosis until all conditions of the checkpoint are cleared and the phosphate group is...

Ras is a GTP-binding protein that is often mutated in cancer cells. Normal cells are stimulated...

Ras is a GTP-binding protein that is often mutated in cancer cells. Normal cells are stimulated to divide by receiving a signal from a growth factor through a receptor tyrosine kinase. When the receptor tyrosine kinase binds the growth factor, Ras is stimulated to bind GTP. Ras in turn activates proteins that promote cell proliferation. A common mutation in cancerous cells causes Ras to behave as though it were bound to GTP all the time. Suppose that there is a...

Protein shape is critical for its function. Give two biological examples of how a protein changing...

Protein shape is critical for its function. Give two biological examples of how a protein changing its shape affects its function.

A protein assay requires the reaction of the protein solution with a protein-binding dye for one...

A protein assay requires the reaction of the protein solution with a protein-binding dye for one minute, followed by measuring the absorbance of the protein-dye complex at 505 nm. The absorbance data for four standard protein solutions and the blank is provided in the table below. The absorbance of each solution was measured three times. Construct a calibration curve using the data in the table, and find the slope (m), intercept (b), and their respective standard deviations using the method...

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