Why is LDL high in diabetes?

Solutions

Expert Solution

Answer : Diabetic dyslipidaemia includes increased triacylglycerol levels and decreased HDL-cholesterol levels.

Regulation of lipid metabolism is influenced by the insulin level in our body. Insulin has an antilipolytic effect in adipose tissue, where it inhibits hormone sensitive lipase.Therefore during the post prandial period there will be inhibition of lipolysis by insulin.

The diabetes patients have increased plasma level of lathosterol ( cholesterol synthesis) and decreased plasma level of campesterol(cholesterol absorption) . Hence plasma cholestrol level hikes.

There is a decrease in number of LDL B/E cell-surface receptors, due to the reduced insulin mediated expression and thus plasma LDL level rises. There will be reduced affinity of LDL towards its receptors and so LDL catabolism is decreased. Also LDLs are easily oxidised in diabetic patients and the oxidised LDLs have decreased affinity for the LDL receptor. Hence plasma LDL level increases due to a slow turnover rates.

Thus LDL is high in diabetic patients.

Nightingale answered 5 months ago

Next > < Previous

Related Solutions

List the various causes of diabetes Define Hypoglycemia and Hyperglycemia and why an individual with diabetes...

List the various causes of diabetes Define Hypoglycemia and Hyperglycemia and why an individual with diabetes would get each one Describe management ideas for this disease

1. List five factors that are related to the high rate of obesity and diabetes in...

1. List five factors that are related to the high rate of obesity and diabetes in school aged children. 2. What are five characteristics of the types of food and meals typically consumed by teenagers? 3. What are three factors that affect teenagers’ eating behaviors? 4. In general, how do the nutritional requirements for older adults compare with those of younger adults?

why is HDL sometimes called "good cholesterol" and LDL termed "bad cholesterol"? and what are some...

why is HDL sometimes called "good cholesterol" and LDL termed "bad cholesterol"? and what are some lifestyle changes that can be made to encourage a healthier ratio of HDL: LDL?

During the uptake of low-density lipoprotein (LDL) by a liver cell, LDL-receptor protein complexes are internalized...

During the uptake of low-density lipoprotein (LDL) by a liver cell, LDL-receptor protein complexes are internalized by endocytosis. The endosomes then fuse with lysosomes, where protein components of LDL are hydrolyzed to free amino acids, while cholesterol esters are hydrolyzed by a lysosomal acid lipase. The LDL receptor itself is not affected by lysosomal enzymes. Why is it important that LDL receptors are not degraded by lysosomal enzymes?

a) Describe the central defect in diabetes and the adverse side effects high levels of blood...

a) Describe the central defect in diabetes and the adverse side effects high levels of blood glucose have on the body. b) How do health effects of this disease vary, and what are the benefits of keeping blood glucose well controlled? c) Discuss the focus of dietary management of type 2 diabetes.

Which infection in diabetes causes the most morbidity and why?

Why is Juvenile diabetes so important in public health

10)Two types of cholesterol transport proteins, low-density lipoproteins (LDL) and high-density lipoproteins (HDL), bind to cholesterol...

10)Two types of cholesterol transport proteins, low-density lipoproteins (LDL) and high-density lipoproteins (HDL), bind to cholesterol and carry it through the bloodstream. Familial hypercholesterolemia (FH) is characterized by high cholesterol levels in the blood, which can lead to cardiovascular disease. FH is associated with a loss-of-function mutation of a gene that encodes LDL receptors in liver cells. Individuals who are heterozygous produce lower-than-normal amounts of the LDL receptors, and individuals who are homozygous for the mutant allele have no LDL...

Uncontrolled Diabetes (high blood sugar, lack of insulin or lack of insulin signaling) can result in...

Uncontrolled Diabetes (high blood sugar, lack of insulin or lack of insulin signaling) can result in keto-acidosis, the blood pH is very low and this can be fatal. What is this? What molecules are involved? How does the lack of insulin contribute to this metabolic imbalance?

Why do you think Type 2 Diabetes is so preventable?

1. Why do you think Type 2 Diabetes is so preventable?2. If you were required to design a teaching tool for diabetes, what would you include as interventions for prevention?

Subjects