Could new mutations or diseases arise through IVP, CRISPR, or PGD?

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Expert Solution

Summary- IVP- is invitro production means development or fertilization out side the body which can be consider as IVM(invitromaturation) and IVF ( invitro fetilization) .

CRISPR is a genome editing tool where Cas9 protein loaded with guide RNA sequence which complements with the target sequence than cas9 nuclease cleaves the DNA sequences, in this process targeted genome editing can be done

PGD- pre implantation genetic diagnosis- is a test where on or two cells car taken out if the embryo to check for genetic disorders

so as we can see IVP & PGD are just processes which nothing to do with mutation or causing diseases

but if CRISPR CAS9 method appiled to for genome editing of the embryo It may introduce mutation which ultimately rise to any diseases. tho crispr is target specific but there are also off targeting also seen in experimental events, so off target would introduce single or multiple mutation that might express as diseases phenotype

gladiator answered 9 months ago

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